Identification of transcription factors involved in cannabinoid biosynthesis and glandular trichome formation – Year two

As an important medicinal plant, Cannabis sativa produces bioactive molecules that provide symptom relief for conditions such as severe cancer pain, nausea and vomiting associated with chemotherapy. The cannabinoid biosynthetic pathway that generates bioactive molecules has been studied for over a decade. However, understanding of transcriptional regulators that control cannabinoid synthesis is fairly limited. The […]

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Improved tools for monitoring primitive human blood development

STEMCELL Technologies is a rapidly growing Vancouver-based Canadian biotech company with more than 500 employees and annual sales of more than $80M worldwide primarily serving the burgeoning stem cell field. Blood stem cells were one of the first type of stem cell to be identified and have been used clinically for many transplantation applications for […]

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Learning from Lax Kwil Ts’iit: Gitga’at Resource Use at Clamstown

Indigenous peoples on the northwest coast have modified marine and coastal ecosystems to enhance food resources, shaping both local biodiversity and ecosystem structure since Time Immemorial. Forest Gardens near villages enhance food plant abundance and diversity, while Clam Gardens and managed clam beds improve clam productivity in the intertidal zone. Today these sites remain vital […]

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High-throughput selection of monoclonal antibodies against GPCRs using a microfluidic single cell screening platform – Year two

Antibodies are biomolecules naturally produced by immune cells, called antibody-secreting cells, to protect against infection and diseases. Each antibody-secreting cell makes a unique type of antibody that binds specifically to a target molecule. A major challenge in developing antibody therapeutics is selecting the most effective antibodies from the billions produced within any given host. Our […]

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Using Machine Learning Software (Deep Anatomical Federated Network) to Analyze Magnetic Resonance Imaging (MRI) Sequences of Anatomical Structures

We aim to enhance AI learning of MR images by providing scans of the pectoralis major, deltoid, and gluteus maximus from young healthy adults to Deep Anatomical Federated Network (DAFNE). DAFNE is a decentralized AI software that improves over time through user refinement. Machine Learning (ML) models enable faster automated analysis, distinguishing anatomical structures and […]

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Generation of rabbit monoclonal antibodies using a microfluidic-based screening platform

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

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Generation of rabbit monoclonal antibodies using a microfluidic-based screening platform – Year two

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

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High-throughput selection of monoclonal antibodies against GPCRs using a microfluidic single cell screening platform

Antibodies are biomolecules naturally produced by immune cells, called antibody-secreting cells, to protect against infection and diseases. Each antibody-secreting cell makes a unique type of antibody that binds specifically to a target molecule. A major challenge in developing antibody therapeutics is selecting the most effective antibodies from the billions produced within any given host. Our […]

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Disinfection of wastewater effluent in low resource and humanitarian contexts

Wastewater is one of the primary point-source contaminants polluting freshwater sources, including shallow groundwater sources. Over 80% of wastewater worldwide is neither collected nor treated and more than 70% of sewered wastewater from human activities is discharged without any form of pollution control, increasing the risk of waterborne diseases. This project, in collaboration with Centre […]

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Thermoplastic Polyurethane Electrolyte Development for eWindows

Miru Smart Technologies (Miru) is developing the next generation of low-cost, energy-efficient, high-quality eWindows for residential, commercial, and automotive industries. Using scalable and adaptable methodologies, electrochromic windows have the potential to yield significant gains in energy efficiency by offsetting user climate control requirements while simultaneously providing a high-quality consumer experience. In Q1 2025, Miru recently […]

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Creating an accessible emergency management communications scorecard for public information

The proposed project will synthesize and create a way for city emergency management agencies benchmark their materials for accessibility. Emergency management agencies are responsible for the protecting communities and coordinating planning and emergency response to ensure safety. This makes effective communication, especially with groups considered to be vulnerable during emergencies, highly critical. This project is […]

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Integration of Speed of Sound imaging on 3D volume acquisitions of prostate specimen

Prostate cancer (PCa) cases are expected to double worldwide by 2040, making early and accurate detection essential. Currently, diagnosing PCa is challenging due to systemic biopsy procedures, which have a low sensitivity of 48%. To improve detection and diagnosis, the research group at the University of British Columbia (UBC) is developing advanced imaging techniques such […]

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