Uteroplacental vascular transformation in hypertensive pregnancy

Healthy pregnancies require major changes in blood flow to support the growing baby. Specifically, the mother’s uterine arteries must widen to allow more blood to reach the placenta, and the placenta must build a complex network of blood vessels to deliver oxygen and nutrients to the fetus. In hypertensive disorders of pregnancy (HDP), these changes […]

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Optimization of gene editing tools into human organoid models

Organoids are powerful cellular models that can advance our understanding of human biology and disease progression. They can be generated from human patient samples and be used to screen the best treatment course for patients, thereby allowing for a personalized therapeutic approach. However, a major challenge facing the organoid field is the lack of standard, […]

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Fault-Seal Analysis at Aquistore

Faulting might be affecting the flow of injected CO2 into the subsurface at the Aquistore Carbon Capture and Storage facility in southeastern Saskatchewan. 3D seismic data indicate that faulting affects the Deadwood Sandstone injection target approximately 100 m to the west of the injection well. The seismic data cannot however image all the structural complexity […]

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Decoding the Developmental Gene Regulatory Mechanisms of Schizophrenia and Bipolar Disorder Using Genetics and Single-Cell Epigenomics Data

This research project will explore how certain genetic differences may increase the risk of developing mental health conditions like schizophrenia and bipolar disorder. These conditions often begin in the teenage years or early adulthood, but researchers believe that early brain development, before and after birth, plays a key role. The intern will use powerful computer […]

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Plasma Proteomic Profiling of Severe Traumatic Brain Injury In Pediatric Patients

Severe traumatic brain injury (sTBI) is a leading cause of mortality and disability in pediatric populations. Surviving patients often face long-lasting neurological deficits exacerbated by primary and secondary injury, necessitating further advancements in prognosis and understanding of sTBI mechanisms. Our project aims to address this issue by identifying differentially expressed proteins present in pediatric sTBI […]

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Enhancing the Accuracy of Digital Twin Simulation with Machine Learning and Predictive Analytics

Manufacturing companies often face challenges like unexpected equipment breakdowns, shifting production needs, and resource shortages or surpluses, which can lead to delays in production schedules. Traditional systems struggle to manage these issues effectively. Our project introduces a better solution using Digital Twin (DT) technology, which creates a real-time digital replica of a factory’s operations. This […]

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Strengthening Rigour in Mixed Methods Research

Mixed methods research—combining quantitative and qualitative approaches—has become increasingly important in psychology and the social sciences for addressing complex, real-world questions. However, there is no shared standard for defining and evaluating rigor across mixed methods studies. This project tackles that gap by conducting a Delphi study, an iterative method of gathering expert feedback to build […]

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Nitrous oxide emissions monitoring and remediation approaches during wastewater treatment using partial denitrification anammox process

Wastewater treatment plants contribute to greenhouse gas emissions through the release of carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O), which are produced during various treatment processes. During biological nutrient removal in wastewater treatment, processes such as activated sludge can generate N2O (a potent greenhouse gas) during total nitrogen removal. Further energy consumption in […]

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Investigation of the Fluid Flow and Heat Transfer in Fluidized Bed Combustor and Fluidized Bed Cooler During the Thermal Sand Reclamation Process to Improve its Performance

Foundries play a crucial role in recycling metals However, they face challenges, especially with sand, which is essential for making molds. During casting, sand gets contaminated from binder materials, making it impossible to reuse and causing environmental issues when disposed of. Sand reclamation, like thermal sand reclamation (TSR), helps by cleaning the sand through burning […]

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Design and Synthesis of Stimuli Responsive Viscosifying Agents for use in Fracturing Fluids

Fluids used in hydraulic fracturing are designed to open fractures and transport proppant along the fracture to ensure conservation of the fracture. Scientists in the industry use commercially available polymers that are produced at low-cost in high volumes for other industries (e.g. water treatment) without really understanding the reasons why these polymers have the desired […]

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