Decoding the Developmental Gene Regulatory Mechanisms of Schizophrenia and Bipolar Disorder Using Genetics and Single-Cell Epigenomics Data

This research project will explore how certain genetic differences may increase the risk of developing mental health conditions like schizophrenia and bipolar disorder. These conditions often begin in the teenage years or early adulthood, but researchers believe that early brain development, before and after birth, plays a key role. The intern will use powerful computer tools to study large public datasets that show how genes are turned on and off in different types of brain cells during early development. The goal is to find out how specific genetic changes might affect brain function in ways that lead to mental illness. The project is based at the Childrens Health Research Institute (CHRI), which focuses on improving child and youth health. This work will support CHRIs mission by helping scientists better understand the early causes of psychiatric disorders, which could lead to earlier diagnosis, better treatment, and improved mental health outcomes for young people.

Faculty Supervisor:

Parisa Shooshtari

Student:

Partner:

London Health Sciences Centre

Discipline:

Computer science

Sector:

Health and Related Sciences & Technology

University:

The University of Western Ontario

Program: