The proposed project consists of developing a validated Excel model allowing strategic positioning of early-stage therapies in the pharmaceutical market according to their attractiveness. This model can be used by investors or researchers and will allow them to see how their drug compares to other molecules already marketed, having failed, or in development, in a […]

Prostate cancer (PCa) is the most frequently diagnosed cancer in Canadian men and the third deadliest. If the majority of PCa are well treated using first line treatments like surgery, radiation and/or androgen deprivation therapy (ADT), a proportion of cases (10%) progress to metastatic cancer. At cellular level, cancer cells can initiate alternative responses to […]

La présente demande concerne le chantier de recherche sur les «Les pratiques juridiques controversées» : Une partie des coûts de la justice est attribuable à des pratiques situées aux limites de la déontologie professionnelle : rapport collusoire entre praticiens, multiplication des dépenses douteuses, honoraires abusifs, exploitation de l’ignorance des justiciables, engagement dans des procédures qui […]

Severe Equine Asthma (or “heaves”) is the most common respiratory disorder affecting horses in stables, and impacts an estimated ~15% of the equine population in the northern hemisphere. Heaves is a chronic condition for which there is currently no cure, and its symptoms are quite dramatic causing severe breathing difficulty for affected horses, making it […]

Non-parametric models such as supervised and unsupervised machine learning algorithms seem to be an interesting choice when trying to extract decision-making signals out of this ever-increasing volume of information. These models have been used extensively in the last decades and are now more relevant than ever thanks to the development of new techniques in artificial […]

This project aims at evaluating whether recent results in deep learning models, trained to exploit weak labels (Hwang, 2016) can serve to extract meaningful lesion localizations from image-level labels, either from individual scans or given a (longitudinal) sequence thereof. To this end, we will scale up existing models that have been shown to work on […]

Heart failure (HF) is a condition that develops after the heart becomes damaged or weakened. HF occurs when the pumping action of the heart is not strong enough to move blood around, especially during increased activity or under stress. In addition, the heart muscle may not relax properly to accommodate the flow of blood back […]

L’industrie avicole représente une force motrice de l’économie canadienne et les antibiotiques ont largement contribué à optimiser cette production. Cependant, le phénomène grandissant de la résistance aux antibiotiques ainsi que les pressions exercées par les gouvernements et consommateurs font en sorte que l’industrie avicole canadienne en est à revoir ses pratiques afin de réduire l’utilisation […]

This research aims at primarily analysing the legal frameworks regulating biofertilizers and biopesticides (also known as ‘biologicals’) in India and Ukraine. After studying and analysing the legal frameworks, and barriers in registration procedures for R&D, trial, transfer, trade, transport and storage of new molecules and microbial strains of agro-biologicals, a draft of alternative regulations will […]

Unsustainable application of chemical fertilizers and pesticides has steadily declined food productivity the world over. Hence, agricultural practices need to evolve to sustainably meet the growing global demand for food without irreversibly damaging the world’s natural resources. Biofertilizers and biopesticides hold the potential to maintain agricultural productivity, while safeguarding agroecosystems and microclimates. While development/consumption of […]

Preterm neonates ill-adapted to the extra uterine environment are prone to increased inflammation in multiple organs and the proinflammatory interleukine IL-1b has been closely implicated in brain injury associated with preterm birth (PTB). One major adverse neuronal outcome for PTB survivors is the greater propensity to develop ischemic brain lesions long after birth. Here, we […]

Preterm neonates ill-adapted to the extra uterine environment are prone to increased inflammation in multiple organs and the proinflammatory interleukine IL-1b has been closely implicated in brain injury associated with preterm birth (PTB). Notably, PTB survivors have a greater propensity to develop ischemic brain lesions long after birth. Here, we hypothesize that the neural vasculature […]