Chronic inflammation is the common denominator for various diseases, including atherosclerosis, age-related macular degeneration (AMD), obesity, type-2 diabetes, liver diseases and even cancers. In most cases, this inflammation is the result of massive pro-inflammatory macrophage infiltration in tissues, due to their aberrant signalling and dysfunction, in presence of fat accumulation. The CD36 scavenger receptor has […]

A higher incidence of colon cancer is reported in populations consuming high amounts of red meat, as well as in patients with inflammatory bowel disease, where gut bacteria participate in the development of inflammation. We found that dietary supplementation with heme, an element found at high levels in blood, is detrimental to gut health and […]

Les tourbières représentent la majorité des milieux humides du Québec et offrent une diversité floristique unique. Cependant, les gradients structurant leur biodiversité restent mal connus. Cette compréhension est toutefois essentielle afin d’orienter adéquatement les choix de conservation. Nos objectifs sont 1) de modéliser la répartition de la diversité floristique des tourbières; 2) d’étudier la dynamique […]

Si les TIC ont permis à la formation de devenir plus accessible et favoriseraient l’engagement et la motivation, les faibles taux de réussite en formation à distance (FAD) posent problème. Les environnements numériques (EN) utilisés dans les formations en ligne enregistrent systématiquement les traces informatiques des activités des apprenants, qui peuvent être combinés avec des […]

A number of fungal pathogens cause life-threatening infections in patients whose immune system is crippled. Among others, these include patients treated with cancer chemotherapy and patients who receive organ or blood cell transportation. Pre-term infants, elderly patients and patients in intensive care units are also at risk of developing life-threatening infections. Moreover, fungi cause very […]

Prostate cancer (PCa) is the most frequently diagnosed cancer in Canadian men and the third deadliest. If the majority of PCa are well treated using first line treatments like surgery, radiation and/or androgen deprivation therapy (ADT), a proportion of cases (10%) progress to metastatic cancer resulting in more than 4 000 deaths annually in Canada. […]

La Prophylaxie pré-exposition (PrEP) du VIH permet de réduire considérablement le risque d’infection pour des individus séronégatifs à haut risque, en particulier les hommes gais et bisexuels, une population où l’incidence du VIH demeure très élevée. Il s’agit de mieux comprendre les déterminants sociaux du recours (ou non) à la PrEP chez des hommes gais […]

AVID100 is an antibody-drug conjugate (ADC) against a validated cancer target that is undergoing IND-enabling studies. Phase I clinical trials are scheduled for late 2016. The monoclonal antibody (mAb) portion of the ADC is currently manufactured using a recombinant CHO clone that fails to meet industrial production yield standards. In order to support clinical phases […]

As the most lethal gynaecological cancer, ovarian cancers not only threaten lives of many women worldwide, but health side effects also burdens the life of millions patients following treatments. Novel therapeutic methods aiming at increasing the long-term survival of patients and decreasing health side effects associated with treatment is critical. We have already found that […]

Il a été suggéré que l’ajout d’un traitement par l’hormone de croissance (GH), pourrait augmenter les taux de grossesse en fécondation in vitro (FIV). Des études effectuées chez les mammifères, ont montré que la GH était importante pour le développement des follicules ovariens. Notre objectif est de déterminer si le taux de grossesse lors des […]

A higher incidence of colon cancer is reported in populations consuming high amounts of red meat, as well as in patients with inflammatory bowel disease, where gut bacteria participate in the development of inflammation. We found that dietary supplementation with heme, an element found at high levels in blood, is detrimental to gut health and […]

This study, based on the archival research in the National Archives in Brasília, aims to research the conception and construction of this city, which became a new capital of Brazil since 1960. More specifically, the investigation focuses on three phases of the elaboration of Brasília: the legislative and executive activities aimed at choosing and promoting […]