Development and Optimization of Freeze-dried Formulations of Ga-68 based cold kit and its performance evaluation by Radiolabeling and Animal Imaging

The student will be involved in the research and development of a novel multi-dose lyophilized vial kit for the preparation of Gallium 68Ga-DOTATOC injection used for the PET imaging of neuroendocrine tumors. This novel kit compared to the currently available ready to use injectable solution, has better shelf life and can be easily shipped to […]

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Centering Youth’s Perspectives on Aggression toward Family/Caregivers in Childhood & Adolescence to Inform Best Practices in Supportive Service Provision in Canada

Aggression toward family/caregivers in childhood and adolescence (AFCCA) is a serious issue that impacts all family members in complex and interrelated ways. Despite its extensive and long-term consequences, there is limited research and even scarcer supports available for young people and their families affected by this form of family violence. Expanding on a pilot project […]

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Signal profiling of 5-HT2A receptors to develop new biased ligands

G protein coupled receptors (GCPRs) are proteins found at the surface of cells are responsible for activating numerous intracellular signaling pathways and thus are involved in regulating about every physiological response. Activation of GPCRs occurs via a diverse array of stimuli as varied as photons, lipids, ions, small hormone or neurotransmitters through to larger peptidic […]

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Conception d’un dispositif autonome et intelligent permettant des mesures de neurophotonique de façon entièrement automatisée et à large échelle chez la souris

En recherche sur le cerveau, l’imagerie et la stimulation cérébrale sur le modèle animal sont des techniques de référence. Dans ces expériences, l’expérimentateur doit manipuler l’animal (la souris le plus souvent), ce qui réduit la qualité de données qui peuvent être collectées. Afin de dépasser cette limitation, une nouvelle stratégie d’acquisition basée sur des cages […]

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Development of non opioid pain therapeutics

Developing safer, more effective treatments for chronic pain has become a major area of research due to the negative side effects of opioids. This project aims to mediate the intelligent design and development of drugs, that will achieve pain relief without the detrimental side effects of addiction and respiratory depression. The proposed research will use […]

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Exploitation of special functions orthogonal on finitedomains of 2D and 3D lattices-Fourier expansions offunctions sampled on lattices

The advantages of digital data (signal functions) processing have made this technique a standard for processing real world analog data in many areas of life, from music industry to seismology. Stored digitally, the data also become less sensitive to physical limitations than their analog counterparts. Other advantages include straightforward low frequency filtering procedures (e.g. as […]

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À vélo pour un meilleur soi

Environ 9% des personnes ayant une déficience intellectuelle (DI) atteignent les recommandations gouvernementales en termes d’ activité physique. Cette réalité est également observée par l’organisme sans but lucratif – Ma deuxième maison à moi – qui offre des services de centre d’activités de jour à des adultes présentant une DI. Une faible motivation à l’activité […]

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Mise en oeuvre d’une stratégie de phytoremédiation novatrice sur un ancien site de production d’explosifs à Brownsburg-Chatham, QC (Orica)

Dans le cadre d’une restructuration, Orica souhaite réhabiliter une partie de son site localisé à Brownsburg-Chatham au Québec. Le site qui accueille depuis 1870 une usine de production d’explosif est non seulement contaminé, mais présente des risques importants pour les écosystèmes et la santé humaine. Ainsi, l’entreprise souhaite développer une approche verte qui vise à […]

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Local in situ Controlled Delivery of Biphosphonates in Bone Metastasis

We propose to develop in collaboration with Medtronic Canada a bioceramic drug delivery system for the local controlled release of Biphosphonates (BP) – drugs that prevent bone resorption – to promote both tumor inhibition and bone regeneration at the site of bone tumor resection, eliminating the need for high systemic doses and side effects associated […]

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