Development of new RNA-guided dual-cleaving nucleases

Gene editing with RNA-guided nucleases based on the CRISPR bacterial defence system (clustered regularly interspaced palindromic repeats) has revolutionized both basic science and therapeutic applications. However, CRISPR associated (Cas) nucleases are not optimized for all types of gene-editing applications. In particular, the double-strand breaks made in DNA by the Cas proteins are imperfectly repaired by […]

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Using Technology for Curriculum-Based Measurement of Literacy

We do not have an effective Canadian Curriculum-Based Measurement Tool. Moreover, existing tools do not incorporate Artificial Intelligence. We aim to develop a tool that will enable the targeted and brief assessment of gaps in student literacy skills with the aim of allowing strategic instruction to be planned and delivered based on those gaps. Identifying […]

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Cost-effective leachate treatment using aerobic granular sludge technology

Landfill leachate is a complex wastewater composed of organic carbon, nitrogen compounds, dissolved solids, and heavy metals. Leachate characteristics may differ depending on the waste landfilled, climate conditions, and landfill age. Because of the toxic and recalcitrant nature of its constituents, landfill leachate wastewater (LLW) must be treated before being released to the environment. There […]

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Le profil du client selon l’aire de diffusion: une application au domaine culturel

Un des gros défis des entreprises culturelles et artistiques est celui de la connaissance de leur public. Cette connaissance est le principal fondement pour la mise en place d’actions marketing pertinentes (Colbert & Dantas, 2019). Certes, les informations fournies par les systèmes de billetterie sont utiles pour la prise de décision. Cependant, ces informations ne […]

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Early Biomarkers for Prediction of Chemotherapy-induced RNA Disruption in Tumour Cells

Chemotherapy agents can induce the degradation of a molecule in tumour cells called RNA. We call this phenomenon “RNA disruption”. High tumour RNA disruption after about 1 month of chemotherapy predicts for complete tumour destruction and improved cancer patient survival. We and Rna Diagnostics, Inc. are using this knowledge to predict patient outcome from chemotherapy. […]

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Documentation et évaluation d’un projet de transition socio-écologique dans une perspective d’amélioration et de mise à l’échelle

La génération de déchets dans le secteur de la restauration a emporté est un fléau. Alors que la Ville de Montréal vient d’adopter un règlement interdisant l’utilisation de plastiques à usage unique, l’entreprise d’économie sociale Retournzy coop propose un modèle innovant d’économie circulaire et de partage de contenants réutilisables consignés sous forme d’un réseau. L’objectif […]

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An Aerodynamic-Acoustic Design of an Electrical and Shrouded Tail Rotor

Aerospace industry innovations targets reduction of fuel consumption and noise emission. Electrical power-bywire enabled technology address these challenges yielding lighter designs, increased operation flexibility and cost reduction. With electric motors having variable rotational speed, constraints in design and optimization strategies for rotor and propellers can be released. ln addition to conventional aircraft and rotorcraft, new […]

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Artificial Intelligence for Condition Assessment of Critical Infrastructure

Unexpected deterioration and failure of concrete infrastructure causes major disruptions and in the most severe cases, results in lives lost. According to the 2019 Canadian Infrastructure Report Card, Canadian public infrastructure is at risk therefore, detecting and addressing deterioration in such structures is crucial. The Damage Rating Index (DRI), a reliable novel quantitative microscopic procedure, […]

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The Pan-Canadian Immunoglobulin Database: Enabling Utilization Reporting and Personalized Treatment Using Data Mining Techniques for Immunoglobulin

Immunoglobulin (Ig) is a blood product that is used for people who either lack IgG antibodies or require immunomodulatory therapy for life-threatening autoimmune conditions. The use of Ig products continues to increase each year, at an average rate of 8%. The COVID-19 pandemic has introduced additional stress on the Ig supply due to a reduction […]

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Developing an Automated Response Characterization Tool Based on Affect, Content, and Linguistic Features of the Casper Test

Open-ended questions are where respondents consider hypothetical scenarios that they might encounter in real life and describe what action(s) they might take in response to each situation. To assess a test-taker’s responses to these questions, a human scoring process (i.e., human raters marking each response individually) is followed. Despite following clear scoring criteria, human raters […]

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