Peripheral T-cell lymphoma (PTCL) is a type of blood cancer with poor treatment outcomes, as patients often relapse or do not respond to available therapies. A key factor driving the growth of cancerous T cells in PTCL is a protein called ITK, which helps these cells survive by activating biological pathways that boost cell growth […]

Huntington’s Disease (HD) is a debilitating neurodegenerative disease marked by progressive loss of motor control and cognitive function. Presently, there are no disease-modifying therapies. A potential avenue for slowing or stopping HD progression is to target huntingtin (HTT), or polyglutamine-expanded mutant HTT (mHTT), for degradation using proteasome targeting chimera (PROTAC) technology. A PROTAC will bring […]

Gingival recession affects ~50% of the population and results in the exposure of tooth root surfaces, which leads to an increased risk of dental caries. The gold standard treatment is autologous grafts involving tissue being harvested from the roof of a patient’s mouth, leading to pain and bleeding, the inability to eat, risk of infection, […]

Amylior Inc., une entreprise spécialisée dans les fauteuils roulants motorisés, travaille sur un projet innovant visant à améliorer la vie des utilisateurs de ces fauteuils. L’objectif est de créer un fauteuil intelligent capable de s’adapter aux besoins spécifiques de chaque personne, en surveillant des paramètres comme la pression et la posture. Cela permettrait de prévenir […]

This project aims to improve the early detection of pressure injuries (PIs) in children with disabilities who wear casts for long periods. PIs occur when continuous pressure over bony areas damages the skin, leading to pain, infections, and longer hospital stays. Currently, it is difficult to monitor the skin under a cast because it cannot […]

Persistent organic pollutants (POPs) are harmful chemicals that threaten marine life and ecosystems worldwide, including majestic creatures like killer whales (Orcinus orca). Despite efforts like the Stockholm Convention treaty to control these pollutants, they persist in the environment and continue to harm wildlife. Killer whales, as top predators, face particular risks due to their position […]

In this project, three different phases including a series of structural tests on a novel full-scale precast fiber-reinforced tunnel lining segments reinforced with FRP composite materials are proposed. The three different phases include (1) Structural testing of novel precast concrete tunnel lining segments in the structural laboratory, University of Sherbrooke; (3) field implementation, application, and […]

We propose to develop a microfluidic device that enables the selection of viable sperm directly from semen via a simple dip approach. The device will feature a chamber incorporating a porous membrane. The sperm selection method involves only two steps – users load the device with a semen sample and place the device in buffer. […]

??Submerged Aquatic Vegetation (SAV) are important in aquatic ecosystems as they represent hotspots of biodiversity and ecosystem functioning. Earth observation technologies (EOT) constitute a cost-effective monitoring tool for environmental variables at large scales but their use in freshwater environmental monitoring remains limited because of the optical complexity of inland waters. This research develops and builds […]

Many patients with mood disorders, which include major depression and bipolar disorder, continue to experience symptoms even after receiving treatment. Traditional research methods have helped improve care but often don’t reflect the realities of clinical practice, which slows progress in applying research to improve services. This project aims to support St. Joseph’s Healthcare Hamilton (SJHH) […]

Polyurethane is a flammable polymer that can release toxic gases when exposed to fire, restricting their application in areas such as pipe liners. This project aims to develop fire-proof polyurethane composites pipe liners with a long cycle time and good stability in harsh environments. Given the increasing demand for advanced materials in industry, we will […]

Mastercard works with improving and securing payments of millions of cardholders and merchants. One of the primary objectives of Mastercard’s work is to detect and prevent fraudulent payments. There are several ways of committing such fraud, often such fraud can happen due to vulnerability of the merchant to such fraudulent threats and several other underlying […]