Regulating Abnormal Connectivity in Posttraumatic Stress Disorder via Real-time fMRI Neurofeedback

Patients with posttraumatic stress disorder (PTSD) are characterized by decreased prefrontal cortex (PFC) regulation on hyperactive emotion generation regions, such as the amygdala. Real-time (rt)-fMRI neurofeedback allows for localized brain regions to be self-regulated through neuroimaging signal feedback. Recently within our lab, learning to decrease amygdala activation via neurofeedback was shown to normalize the neural […]

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Process optimization for extraction of compounds from natural sources – Year Two

Various methods have been developed to extract compounds from fruits, vegetables, and seeds. Subcritical and supercritical extractions are the most promising techniques with high output qualities and high cost efficiencies. Running the systems at different pressures and temperatures, the essential bi-product can be extracted from the natural compounds matrix. In addition to their effectiveness, the […]

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Regulating Abnormal Connectivity in Posttraumatic Stress Disorder via Real-time fMRI Neurofeedback – Year two

Patients with posttraumatic stress disorder (PTSD) are characterized by decreased prefrontal cortex (PFC) regulation on hyperactive emotion generation regions, such as the amygdala. Real-time (rt)-fMRI neurofeedback allows for localized brain regions to be self-regulated through neuroimaging signal feedback. Recently within our lab, learning to decrease amygdala activation via neurofeedback was shown to normalize the neural […]

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Zero-Emission Public Transit Fleet Systems

Electrification of transit vehicles is a part of Ontario’s long-term strategy to reduce transportation-related greenhouse gas (GHG) emissions. However, transit agencies and utility/local distribution companies face significant technological and operational hurdles in integrating “off the shelf” electric bus technologies. The postdoctoral fellow collaborating with Canadian Urban Transit Research & Innovation Consortium will work with transit […]

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Zero-Emission Public Transit Fleet Systems – Year two

Electrification of transit vehicles is a part of Ontario’s long-term strategy to reduce transportation-related greenhouse gas (GHG) emissions. However, transit agencies and utility/local distribution companies face significant technological and operational hurdles in integrating “off the shelf” electric bus technologies. The postdoctoral fellow collaborating with Canadian Urban Transit Research & Innovation Consortium will work with transit […]

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Examining Post-Implementation Pass Rates of Canadian Wildland Fire Fighters on their Physical Employment Standard.

Wildland fire fighting is a physically demanding public safety occupation. Front-line wildland fire fighters (WFF) must have an appropriate level of job-related fitness for safe and efficient work performance. Beginning in 2011, it was required that all WFF must demonstrate that they are capable of meeting the rigorous physical demands encountered during an initial attack […]

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Analysis of protein interaction complexes by advanced mass spectrometry workflows

The analysis of protein-protein interactions is critical for understanding cell growth control, and how aberrant connections contribute to cancer and other diseases. Mass spectrometry is a critical tool in this field, but sample complexity, instrument dynamic range and resolution limit some applications. This project will evaluate the use of the SelexION ion mobility device and […]

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Optimization of the immune response against transferrin receptor based vaccines

The bacterial transferrin receptor is considered to be a potentially efficacious candidate vaccine antigen against pathogens important in human disease and in animal husbandry. Previous data suggests that transferrin receptor-based antigens can elicit protection from both invasive disease and potentially from asymptomatic colonization. One major consideration when developing vaccines is the choice of adjuvant, a […]

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Analysis of protein interaction complexes by advanced mass spectrometry workflows – Year Two

By studying protein complexes, scientists gain insight into how cells are regulated and how aberrations in protein-protein interactions cause disease. Mass spectrometry is a technology that allows proteins to be identified and quantified in a systematic and unbiased manner. New technologies from mass spectrometer vendor SCIEX aim to improve the throughput, accuracy and reproducibility of […]

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Validation of novel neurofeedback training engine for improving brain health in aging and neurodevelopmental disorders

Memory impairment is the most common cognitive complaint among older adults. On the other side of the developmental spectrum, young adults that have been diagnosed with Autism Spectrum Disorders (ASD) have difficulty adapting flexibly to changing social circumstances. These memory and social deficits disrupt every day living. At present, promising interventions based on research using […]

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Validation of novel neurofeedback training engine for improving brain health in aging and neurodevelopmental disorders – Year two

Memory impairment is the most common complaint associated with aging. Promising interventions based on research are generally reserved for clinical settings. Technological advancement has now made it possible to administer neurofeedback, an established technique for self-regulating brain waves, using portable technology. xSensa Labs, the partner organization, has developed a digital solution that translates research protocols […]

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Multi-level modeling methodologies for aircraft thermal architecture optimization

The proposed project will contribute to Bombardier’s research initiative “Virtual Aircraft” with the overall objective to improve modeling and simulation throughout the development process to enable innovation and reduce development risk through extensive design space exploration. The objective is to develop models of thermal aspects, traditionally investigated later in the design, when the aircraft architecture […]

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