Characterization of candidate chemical probes for WDR91 and investigation of its function in endosomes

Target 2035 is an ambitious goal supported by the Structural Genomics Consortium (SGC) to develop pharmacological modulators of all proteins encoded within the human genome by the year 2035. These compounds, referred to as chemical probes, are made available to the public and enables researchers to investigate biological processes in a more effective manner. The development of chemical probes leads to future research discoveries, especially for proteins with functions that are not well understood and those have avoided attention by scientists due to high risks associated with their investigation. Fostering collaboration between industry and academia will be a necessity to make Target 2035 a possibility. The proposed project will encourage collaboration between SGC, Pharma partners, and academics to develop and characterize candidate chemical probes for WDR91, a protein with limited functional insights associated with endosomes and intracellular trafficking. The intern will establish assays to evaluate WDR91 compound target engagement in cells and use the compounds to interrogate the biological function of this protein. To this end, the intern will contribute towards an important and necessary goal for the development of high quality chemical probes.

Faculty Supervisor:

Dalia Barsyte-Lovejoy

Student:

Partner:

Structural Genomics Consortium

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Toronto

Program: