Improved tools for monitoring primitive human blood development

STEMCELL Technologies is a rapidly growing Vancouver-based Canadian biotech company with more than 500 employees and annual sales of more than $80M worldwide primarily serving the burgeoning stem cell field. Blood stem cells were one of the first type of stem cell to be identified and have been used clinically for many transplantation applications for […]

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High-throughput selection of monoclonal antibodies against GPCRs using a microfluidic single cell screening platform – Year two

Antibodies are biomolecules naturally produced by immune cells, called antibody-secreting cells, to protect against infection and diseases. Each antibody-secreting cell makes a unique type of antibody that binds specifically to a target molecule. A major challenge in developing antibody therapeutics is selecting the most effective antibodies from the billions produced within any given host. Our […]

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Generation of rabbit monoclonal antibodies using a microfluidic-based screening platform

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

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Generation of rabbit monoclonal antibodies using a microfluidic-based screening platform – Year two

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

Read More
High-throughput selection of monoclonal antibodies against GPCRs using a microfluidic single cell screening platform

Antibodies are biomolecules naturally produced by immune cells, called antibody-secreting cells, to protect against infection and diseases. Each antibody-secreting cell makes a unique type of antibody that binds specifically to a target molecule. A major challenge in developing antibody therapeutics is selecting the most effective antibodies from the billions produced within any given host. Our […]

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Education in the field; using behavioral wildlife research to inform the interpretive program of an eco-tourism operation – Year two

Knight Inlet Lodge is an eco-tourism resort specializing in grizzly bear viewing, and caters to both national and international clients. The business requires research to improve their interpretive program by informing guide naturalists on the function of observed bear behaviour. Research is required to: 1) assess the relatedness and movements patterns of regularly observed bears, […]

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Using brain monitoring and video surveillance to reduce violent incidents in a care-facility environment – Year two

Increasingly prevalent patient violence within the dementia population is a challenge to long term care providers. Violent incidents can lead to serious musculoskeletal and neurological health complications. I propose to use video surveillance and a novel brain monitoring system in a care facility-based elderly population, to monitor violent episodes and brain vitality after incidents. This […]

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Education in the field; using behavioral wildlife research to inform the interpretive program of an eco-tourism operation

Knight Inlet Lodge is an eco-tourism resort specializing in grizzly bear viewing, and caters to both national and international clients. The business requires research to improve their interpretive program by informing guide naturalists on the function of observed bear behaviour. Research is required to: 1) assess the relatedness and movements patterns of regularly observed bears, […]

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Comparative effectiveness, and network meta-analysis of pre-insulin oral hypoglycemic drugs in the treatment of type II diabetes

The proposed project is two-phased. The first phase involves a study that will use specialized research analysis techniques to compare the effectiveness of pharmaceutical drugs used to treat type II diabetes and to identify if a group of drugs are producing similar benefits in terms of controlling the disease. The applicant’s clinical and epidemiological background […]

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Developing a robust AI pipeline for clinical trials using digital devices: Integrating sample size estimation, data quality assessment, and AI for enhanced medical screening

Cardiovascular disease is a major global health challenge, and early prevention is crucial to reducing its impact. This project explores how wearable devices and artificial intelligence (AI) can improve early detection and prevention of heart disease. Wearable sensors continuously collect health data, but challenges such as missing information and inaccurate readings limit their reliability in […]

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Comparative effectiveness, and network meta-analysis of pre-insulin oral hypoglycemic drugs in the treatment of type II diabetes

The proposed project is two-phased. The first phase involves a study that will use specialized research analysis techniques to compare the effectiveness of pharmaceutical drugs used to treat type II diabetes and to identify if a group of drugs are producing similar benefits in terms of controlling the disease. The applicant’s clinical and epidemiological background […]

Read More
Using brain monitoring and video surveillance to reduce violent incidents in a care-facility environment

Increasingly prevalent patient violence within the dementia population is a challenge to long term care providers. Violent incidents can lead to serious musculoskeletal and neurological health complications. I propose to use video surveillance and a novel brain monitoring system in a care facility-based elderly population, to monitor violent episodes and brain vitality after incidents. This […]

Read More