Post Discharge Survival Project

Most countries in Africa are not set to meet their 2015 targets of a two thirds reduction in under-5 mortality. Among the areas of child health most neglected is care following hospitalization. More children die in the weeks following discharge than during hospitalization, yet no strategy exists to improve these outcomes. My research over the […]

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Post Discharge Survival Project – Year two

Most countries in Africa are not set to meet their 2015 targets of a two thirds reduction in under-5 mortality. Among the areas of child health most neglected is care following hospitalization. More children die in the weeks following discharge than during hospitalization, yet no strategy exists to improve these outcomes. My research over the […]

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Snow avalanche risk management

Managing the risks from snow avalanches during winter mountain travel is vital for the Canadian avalanche industry. An average of 14 avalanche-related fatalities per year occurred between 1997 and 2014 with the majority of those triggering the avalanches themselves. We propose a detailed examination of avalanche risk management practices using the conceptual model for avalanche […]

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Snow avalanche risk management – Year two

Managing the risks from snow avalanches during winter mountain travel is vital for the Canadian avalanche industry. An average of 14 avalanche-related fatalities per year occurred between 1997 and 2014 with the majority of those triggering the avalanches themselves. We propose a detailed examination of avalanche risk management practices using the conceptual model for avalanche […]

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Lie Group Harmonic and Statistical Analysis of Human Movement

Statistical and harmonic analysis of 3-dimensional motions of objects or humans are instrumental to establish how these motions differ, depending on various influences. When such motions involve no tearing, they may be described by elements of the Euclidean Group. Algorithms developed in the author’s Ph.D. dissertation exploit the unique properties of Conformal Geometric Algebra to […]

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Improved tools for monitoring primitive human blood development – Year two

STEMCELL Technologies is a rapidly growing Vancouver-based Canadian biotech company with more than 500 employees and annual sales of more than $80M worldwide primarily serving the burgeoning stem cell field. Blood stem cells were one of the first type of stem cell to be identified and have been used clinically for many transplantation applications for […]

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Identification of transcription factors involved in cannabinoid biosynthesis and glandular trichome formation

As an important medicinal plant, Cannabis sativa produces bioactive molecules that provide symptom relief for conditions such as severe cancer pain, nausea and vomiting associated with chemotherapy. The cannabinoid biosynthetic pathway that generates bioactive molecules has been studied for over a decade. However, understanding of transcriptional regulators that control cannabinoid synthesis is fairly limited. The […]

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Identification of transcription factors involved in cannabinoid biosynthesis and glandular trichome formation – Year two

As an important medicinal plant, Cannabis sativa produces bioactive molecules that provide symptom relief for conditions such as severe cancer pain, nausea and vomiting associated with chemotherapy. The cannabinoid biosynthetic pathway that generates bioactive molecules has been studied for over a decade. However, understanding of transcriptional regulators that control cannabinoid synthesis is fairly limited. The […]

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Improved tools for monitoring primitive human blood development

STEMCELL Technologies is a rapidly growing Vancouver-based Canadian biotech company with more than 500 employees and annual sales of more than $80M worldwide primarily serving the burgeoning stem cell field. Blood stem cells were one of the first type of stem cell to be identified and have been used clinically for many transplantation applications for […]

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High-throughput selection of monoclonal antibodies against GPCRs using a microfluidic single cell screening platform – Year two

Antibodies are biomolecules naturally produced by immune cells, called antibody-secreting cells, to protect against infection and diseases. Each antibody-secreting cell makes a unique type of antibody that binds specifically to a target molecule. A major challenge in developing antibody therapeutics is selecting the most effective antibodies from the billions produced within any given host. Our […]

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Generation of rabbit monoclonal antibodies using a microfluidic-based screening platform

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

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