Supramolecular chemists have constructed macrocyclic structures called “hosts” that can selectively encapsulate a small molecule “guest.” Selective recognition is instrumental when trying to take host-guest chemistry to the real world. Drug detection, reversal, and delivery are growing applications for host-guest chemistry. However, things become complicated in biological systems due to the presence of salts that […]

Obesity is a well-known risk factor in many diseases, including diabetes, cancer, and heart disease, in part due to abnormal blood vessel development with fat tissue. During weight gain, the volume of fat tissues can undergo drastic changes. Normally, when new tissues develop, there is a corresponding increase in blood vessel density via a process […]

Asthma is a common disease of airways affecting 339 million people worldwide. About 5-10% of asthma patients have severe asthma, which is associated with disproportionately high risk of exacerbations (‘lung attacks’) and death. It also contributes to nearly 50% of asthma-related healthcare spending. In particular, exacerbations are a major source of burden in severe asthma. […]

Conventional molecular discovery relies on high-throughput screening strategies (HTS) to identify molecules that match a specific set of user-defined properties. Unfortunately, due to the enormous size of chemical spaces (10^60 molecules in the case of the drug-like chemical space), HTS is usually performed over pre-built chemical libraries of moderate size, often by employing computational/AI methods […]

Ce projet de recherche est basé sur l’étude de mouvements « numériques » s’étant développés sur le réseau social Twitter. Cet outil de microblogging développé en 2006, permet aujourd’hui, à tout un chacun de facilement y donner son opinion sur divers sujets/débats et d’y prendre part (en publiant une photo, en utilisant un certain hashtag, […]

The aim of this project is to develop novel optical and microfluidic methods to extract quantitative metrics from biological interactions. Such quantitative information will be used to understand biophysical processes – such as binding of antibodies to a cell or tissue surface as well as improving decision making in diagnostic pathology. Towards these aims, we […]

Shape Memory Alloys (SMA) are smart materials capable of recovering large inelastic strains. SMA are therefore excellent candidates for applications where deformation needs to be controlled remotely. One of the main challenges holding back a wider acceptance of SMA is their poor workability leading to high tool wear when manufactured by machining. Additive Manufacturing, also […]

Le développement professionnel des enseignants est reconnu comme un levier incontournable d’amélioration des systèmes éducatifs. Après des décennies de recherches consacrées à l’apprentissage par la formation, l’apprentissage « informel » (Kyndt et al., 2016; Lecat et al., 2020) ou « au et par » le travail (Bourgeois & Mornata, 2012) occupe dorénavant le centre de […]

The creation of innovative acrobatics is difficult for coaches due to the interaction of physical principles involved in simultaneous rotations on multiple axis. Numerical simulation can be useful to generate acrobatics without involving supplementary risks for the athletes. However, the accuracy of the simulation is important if we want athletes to try the new techniques […]

Climate change caused by accumulative CO2 emission (due to the rapid development of human industry) has become an imminent threat to human beings as witnessed by the more and more frequent reports on sea-level rising, storm, and wildfire. The close-loop CO2 recycling, including CO2 capture, storage, and utilization has thus attracted enormous attention from researchers […]

Le projet présenté ici porterait sur la mobilité de Maeva Genin dans le cadre d’un stage indoc de 4 mois à l’Université de Montréal au sein du CEDAJ, sous la supervision de Isabelle V. Daignault et de Nathalie Fontaine (co-directrice du CEDAJ). L’objectif de cette mobilité serait de collaborer sur l’analyse des résultats d’un projet […]

Les dirigeants politiques ont une capacité limitée à prêter attention à plusieurs sujets en même temps tandis que les médias agissent comme un signal de l’importance des problèmes saillants d’une société donnée. Par conséquent, les médias influencent souvent fortement le choix des thématiques devant être intégrées à l’agenda politique. Ainsi, la littérature a montré qu’il […]