Sunitinib and pazopanib are two effective medications from tyrosine kinase inhibitor pharmacologic class for the first-line treatment of metastatic renal cell carcinoma (mRCC). Nevertheless, the adverse side effects during treatment often lead to dose reductions or even treatment discontinuations. In order to provide the most efficient treatment to mRCC patients, efficacy and safety of these […]

This project is being undertaken as a part of the Gait Rehabilitation Analysis for Amputee Locomotion (GRAAL). GRAAL is a 3-year project focused on the continued rehabilitation of people with lower limb amputations. Through this research I will use gait analysis technology to kinetic measures of gait including ground reaction forces and muscle torque and […]

Depuis quelques années, les travaux en entrepreneuriat indiquent une prévalence d’entrepreneurs « hybride », soit le fait de conserver un emploi salarié tout en démarrant et opérant une entreprise (Folta et al., 2010). Bien peu de choses sont connues quant à ce phénomène, notamment ce qui fait en sorte qu’une personne choisisse de demeurer dans […]

Bone defects may arise from trauma, congenital disease, tissue/vascular necrosis or tumor radiotherapy/excision. Rising rates of the ageing population are expected to dramatically increase the demand for orthopaedic procedures and associated waiting periods for patient treatment. Current techniques to repair and regenerate of mineralized tissues possess inherent limitation and may be overcome by tissue engineering. […]

Un problème récurrent en mathématique est de trouver un ensemble de nombres, appelés invariants, qui ne changent pas même si l’on modifie selon certaines règles un objet donné. Par exemple, l’aire et le périmètre d’un triangle restent invariants après translations, rotations et symétries; ces nombres sont donc des invariants. Nous étudions un concept mathématique appelé […]

L’objectif de cette recherche sera de faire une étude des traces littéraires mexicaines autochtones restant de la colonisation mexicaine afin d’éclairer cette difficile cohabitation sur le territoire américain et plus particulièrement d’établir, à partir de ces recherches, un comparatif avec le thème de l’hospitalité dans la littérature canadienne autochtone actuelle. Ces recherches seront à la […]

This research project as three main objectives: (1) to research and document Chuj, an underdocumented Indigenous Mayan language spoken in Guatemala and Mexico by approximately 45,000 speakers; (2) to conduct fieldwork in a Chuj speaking community in Mexico where I will learn more about Chuj language and culture; and (3) to meet with and learn […]

Numerous studies have shown the necessity of supportive close relationships in our lives, and how the presence of social support can greatly protect us against stress, depression, and also enhance our perceived quality of life. Furthermore, previous studies have suggested that – throughout evolutionary time – our need for close relationships has primarily developed the […]

Bi-functional metal oxide electro-catalyst for energy application are a novel area of research with application mainly in energy storage and conversion device. They enable a single device to perform oxidation and reduction reaction subsequently, which reduces the cost and increase the versatility of energy storage and conversion technology such as fuel cell, electrolyser and flow […]

Les polymères thermoplastiques renforcés de fibres naturelles s’ offrent une gamme intéressante de propriétés mécaniques spécifiques combinées à une empreinte environnementale maîtrisée. Mais, en raison de la faible résistance thermique des fibres végétales, la plupart des voies de traitement appliquées à ces biocomposites, y compris, le moulage par injection, etc., ont un effet important sur […]

ABC-transporters is a superfamily of membrane proteins that are expressed in prokaryotes and eukaryotes. One of the most studied ABC transporters is P-glycoprotein (Pgp). Pgp remove chemotherapy drugs from inside the cancer cell. Therefore, higher concentrations of toxic chemotherapy drugs are needed to kill cancer cells. This has an adverse effect: cancer cells develop resistance […]

The proposed research project aims to gain novel insight into the mechanism of action of a key protein complex involved in the synthesis of plant starch. This aim will be achieved through the interdisciplinary collaboration of researchers at Guelph and Lille, having complementary expertise in both protein biochemistry and structural biology. The PhD student from […]