Role of TIPARP and AHR in gene regulation triggered by the environmental contaminant PCB126

The overall goal of our work is to use novel genetically modified rodent models to determine how two gene regulatory proteins known as ‘TIPARP’ and ‘AHR’ interact to influence mammalian responses to an important class of chemical toxicants that are found in certain foods and in the environment. These include the potential pesticide contaminant dioxin (TCDD), the industrial coolant component PCB126, and the cruciferous vegetable-derived compound indole-3-carbinol (I3C). Our studies are also examining the role of the TIPARP-AHR interaction in fatty liver disease, obesity and inflammatory bowel disease, and may identify novel signaling pathways that are activated by environmental contaminants of relevance to human health. This summer Chi Pham will participate in the comparative analysis of tissue specimens obtained from wild-type and TIPARP-deficient mice that have been exposed to PCB126, and her results will provide important information to allow us to compare the responses of these mouse strains with those observed in our previous studies using TCDD exposure.

Faculty Supervisor:

Denis Grant

Student:

Partner:

University of Oslo

Discipline:

Life Sciences

Sector:

Health and Related Sciences & Technology; Environmental Science and Technology; Pharmaceuticals

University:

University of Toronto

Program: