Targeting Radiation-Induced CXCL12/CXCR4 Signaling and the Immune Microenvironment to Improve the Radio-Curability of Human Cancer

Medical images were collected from cervical tumors from mice undergoing cancer treatment using radiation to kill cancer cells and shrink tumors. The purpose is to discover new biological molecules and observe the immune system reacts during radiation treatment. These images will be analyzed by MATLAB, which is a computer platform. MATLAB will perform a couple […]

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Sales Micro-Patterns: ML-driven detection of deviant Store/SKU sales patterns

For almost a century, Canadian Tire has been offering products and services to help Canadians with the jobs and joys of life in Canada. Today, with a network of over 1,700 retail locations, Canadian Tire is dedicated to improving products and services offered to the community they serve. With this project, the company aims to […]

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Investigation and Development of an Automated Testing Platform for Digitally Implemented Clinical Guidelines in the Health Level (HL7) Fast Healthcare Interoperability Resources (FHIR) Standard

The project partner, JuniperCDS (Juniper), is a digital health company that is developing a care and treatment planning (software) application called JuniperCDS, which is a clinical decision support software solution that enables clinicians to create meaningful, person-centric care plans by delivering in-context recommendations based on the latest clinical guidelines at the point of care. A […]

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Evaluation of Therapeutic Natural Killer cells

Cellular immunotherapy has yielded numerous clinical benefits in treating cancer. While many successes involve CAR T cells, unfortunately this potent anticancer cell therapy can cause serious and even fatal complications. Another immune cell, the natural killer cell (NK), may lead to effective treatment without unwanted side-effects. Furthermore, the use of stem cell-derived NKs provides additional […]

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Rigidity of Pham-Brieskorn Threefolds

Algebraic geometry is generally concerned with understanding the properties of geometric objects defined by polynomial equations. These geometric objects, called “varieties”, are points, curves, surfaces and higher dimensional objects. To each variety there is an associated abstract object called a “commutative ring”. It is interesting to try to determine whether a variety contains a certain […]

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Ultrafast Laser Interaction for Chemical and Topological Functionalization of Metallic

This project is to understand the chemical modifications induced by laser irradiation leading to the formation of periodic nanostructures on the surface of metals. Such a study is very significant since it will allow to tune metallic surface properties to control for instance wettability, i.e. whether surfaces are hydrophillic (attract water) or hydrophobic (repel water). […]

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Development of mixed wettability surface for high yield solar desalination

This project focuses on developing a mixed wettability surface to improve the freshwater yield of a solar thermal desalination system. The solar desalination system that will be used for this project is the solar still system. The objective is to find the optimized ratio of high wettability to low wettability area on a polymeric surface […]

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Joint Research Program in Atmospheric Chemistry

The objective of this international collaboration between P.M. Mayer and J. Giorgi at the University of Ottawa and Maxi Burgos Paci at the Universidad Nacional de Córdoba is to understand the fate of reactive organic carbon in the atmosphere. Reactive Organic Carbon (ROC) includes a wide diversity of chemicals that react with atmospheric gases, free […]

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Effects of host plant quality on the transcriptional signatures of flight in migratory butterflies

Migratory insects surpass migratory terrestrial vertebrates in biomass and play essential roles in global ecosystems and agroecosystems serving as pollinators, biological control, or food and nutrient sources. They can also have detrimental effects as vectors of plant and animal diseases or as ecological pests. It is therefore essential for food, ecological, and human security to […]

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Novel Inhibitors of Tissue Transglutaminase

Tissue transglutaminase (TG2) is a protein that is able to mediate the cross-linking of other proteins. The unregulated activity of TG2 is implicated in fibrosis, celiac disease as well as cancer cell survival. Blocking this activity has been shown to decrease tumour size and growth in mice. We have previously designed small molecules that are […]

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