Identification of STAT3/5 Advanced Preclinical Candidates

It is estimated that 1 in 2/3 people will be diagnosed with cancer in their lifetime. Cancer is a genetic disease characterized by the uncontrolled growth of cells. While treatments are available for many cancers, remission of the disease, side-effects of the medication, and the onset of resistance by the cancer to the drugs being […]

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Design and Testing of Innovative Precast Concrete Structures for Railway Infrastructures using FRP Reinforcement and Fibre-Reinforced Concrete

SYM-TECH Inc. is looking to develop new corrosion-free precast concrete members (sleepers and piles) reinforced with fiber-reinforced-polymer (FRP) rods and using fiber reinforced concrete (FRC) for railway foundation applications. Such precast concrete members are usually reinforced with conventional or pre stressed steel reinforcements. Steel bars and strands used for reinforcement have a limited service life […]

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Development of in vitro assays for identification of novel natural products that enhance muscle growth

For the majority of people, weight training builds skeletal muscle, which results in health benefits (e.g., improved disease risk and lifespan). However, despite training, some individuals have trouble gaining muscle (nonresponders). This lack of a response is likely related to an impaired ability to make new proteins (impaired activation of protein synthesis), and there is […]

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Developing Vitamin D Therapies to Block Progression of Chronic Kidney Disease

Chronic kidney disease is a growing problem in Canada and worldwide and is associated with obesity, diabetes and vascular disease. Current therapies only treat symptoms of CKD and have no impact on inflammatory and fibrotic process that underlie the progression of the disease toward hemodialysis, kidney transplantation, or death. OPKO Canada (Markham, Ontario) is developing […]

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Mexican Mining Policy and its Relationship with Canadian Investment

Currently, Mexico receives more international investment in the mining sector than any other Latin American country. Throughout the past five years Canadian private investment has accounted for between 70-75% of all international investment. This project aims to explore Canadian investment in the Mexican mining industry in order to determine how, why and when investment occurs. […]

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Examining how maternal stress and rearing environment enrichment influence offspring performance in commercially-farmed Chinook salmon

Handling practices commonly used in aquaculture can be stressful for spawning fish. When a fish is repeatedly exposed to stressors, circulating levels of the hormone cortisol are chronically elevated, which can cause elevations in egg cortisol. When egg cortisol levels are increased, offspring quality is reduced. Compounded with these intergenerational effects is the influence of […]

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Quantitative Brain PET/MRI

Recently, positron emission tomography (PET) and magnetic resonance imaging (MRI) have been successfully combined into a single system that can collect clinical PET/MRI data simultaneously (Siemens Biograph mMR). With PET, a wide variety of tracers have been developed that can measure energy usage and concentrations of disease-specific features in the brain. In collaboration with Siemens […]

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3D object detection and pose estimation using RGBD cameras

3D object detection and pose estimation (ODPE) is an important area in computer vision, which has many real world applications such as robotics and augmented reality. Estimating an accurate pose from RGB cameras alone is challenging. Given the increased popularity of RGBD sensors, such as Microsoft Kinect, we propose a hybrid method for ODPE based […]

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Enhanced Storage Systems in IOS and Analytics platforms

The internship will be divided into two parts (4 months each). In the first half, I will be working with Freshbooks´ IOS product. They currently use apple’s data storage called Core Data. It’s an internal data storage system that is built-in to the phone, and allows the application to work without an internet connection. I […]

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