RPB1 promoter and UTR regulation

This research project focuses on regulating the levels of the catalytic subunit RPB1 of RNA polymerase II (RNAPII) in complex eukaryotic organisms. Dr. Svejstrup’s lab has engineered a degradable cell line to rapidly adjust RPB1 levels, allowing the exploration of regulatory elements in the POLR2A gene. The aim is to identify promoter regions sensitive to […]

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Recording the developmental plasticity of a mammalian brain in DNA tapes

The chart of synaptic connections within a mammalian brain will serve as a reference map for generations, rivaling the impact of reference genomes. However, such maps have been elusive because current microscopy-based methods do not scale and necessitate sample destruction, losing the developmental history of synapses. We propose a novel “DNA tape” system that uses […]

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Co-construction d’un programme de pair aidance en oncologie : regards croisés France – Québec

La pair-aidance est un mode d’accompagnement entre pairs qui composent ou ont composé avec des expériences de vie difficiles de même nature. Au cours cet accompagnement un pair-aidant (PA) met à disposition d’autres patients son savoir expérientiel, issu de sa vie avec la maladie, pour offrir un soutien émotionnel, expérientiel et informationnel aux patients accompagnés. […]

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Mobilisation de l’approche par concordance de script en formation professionnelle

Le développement de compétences professionnelles chez les travailleurs pose des défis majeurs aux entreprises de tous les secteurs. Les enjeux pour la productivité de compétence sont notables et reposent souvent sur les difficultés du transfert des compétences entre les travailleurs expérimentés et les novices. Cette recherche porte sur une piste de formation ayant fait ses […]

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Comparative Insights of Cultural Influence on Classroom Management in Grades 4 to 8: Exploring Chinese and Canadian Educational Philosophies, Practices, and Intercultural Exchanges

The objectives of this Globalink research project are to study in China and compare it to that of Canada, more specifically the philosophy behind teachers, classrooms, and schools. One sub- objective includes comparing the difference between China and Canada’s teaching philosophies. For example, what specifically do these countries do differently in the grades 4 – […]

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Sherry Shu: Using Artificial Intelligence and Machine Learning to Innovate in the Canadian Fintech Landscape

This project aims to identify new technological approaches to personal finance to bring into the Canadian market. Managing personal finance is critically important for Canadians, especially in a post-pandemic era of economic difficulty and high prices. The project will use customer research related to fintech and artificial intelligence in Malaysia to investigate potential areas for […]

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Characterization of the interface between biomaterials and proteins/cells in the presence of nanotopography

While most of the literature focuses directly on cellular response to biomaterials, cell attachment and behaviour is mediated by the proteins attached to the material. The composition and characteristics of such proteins is dependent on the substrates’ properties, both chemical, physical and mechanical. However, how surface characteristics control protein-material interactions still requires further investigation. The […]

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Making Meaning of International Intercultural Reciprocal Learning in Pre-service Teacher Education: Narratives of Canadian Novice Teachers

This proposed project aims to inquire into Canadian novice teachers’ induction by exploring the long-term impact of international intercultural learning experiences they had during their pre-service teacher education. More specifically, my study expects to answer the three key questions: 1) What are the professional experiences of the Canadian participants in the Reciprocal Learning Program as […]

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Circulating micro-RNAs associated to the aerobic exercise cardiovascular benefits during pregnancy

Physical activity during pregnancy has been related to benefits for both, mother and fetus, mainly by improving cardiovascular health. However, molecular mechanisms involved in these adaptations are not fully described. Micro-RNAs (miRNAs) are noncoding-RNAs which may influence gene expression. miRNAs levels are altered in response to nutrition and lifestyle interventions, including exercise. Some miRNAs are […]

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Estimating Optimal Treatment Regimes from Electronic Health Records using Natural Language Processing for Unmeasured Confounding

n precision medicine, optimal dynamic treatment regimes (DTR) are a sequence of decision rules that individualize medical treatments. DTR estimation methods use observational data, such as electronic health records (EHR), which may lack variables that capture doctors’ rationale behind treatment assignment. However, while such variables, also referred as confounders, may not be directly recorded in […]

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