Acute lymphoblastic leukemia (ALL) is the most common hematological cancer in children. 10 to 15% of pediatric cases are of T cell origin (T-ALL). Current intensive multidrug therapy can achieve high cure rates, yet associated with serious long-term adverse effects, including secondary cancers. Moreover, 15% of children will relapse, facing a poor prognosis. We previously […]

Infrastructure facilities in Canada and many other places worldwide continuously deteriorate. Most structures either reached or exceeded their design service life. Bridges, buildings, roads, and other facilities deteriorate over time. To ensure the safety of these structures, visual inspections are routinely carried out by trained engineers. However, these visual inspections have some critical disadvantages, such […]

Due to modification ease, cost, and time-saving benefits, computational-based methods through the use of Finite Element Analysis (FEA) software programs is the main approach besides physical testing (accelerated durability laboratory test, in-service drive tests) for evaluating the life of welded structures in several industries. Based on guaranteed functionality, integrity, and life cycle robustness requirements in […]

Pour appuyer l’ingénieur lors de la conception, un nouvel outil d’optimisation structurelle basé sur l’apprentissage profond sera conçu afin de diminuer le temps requis pour générer des concepts préliminaires. Cet outil tirera profit des récentes percées dans le domaine de l’apprentissage par renforcement profond, afin d’entraîner un agent décisionnel autonome à accomplir la tâche d’optimisation. […]

Les personnes vivant avec un spina-bifida et/ou l’hydrocéphalie (SBH) font face aux enjeux du vieillissement pouvant complexifier les défis de participation sociale. Or, les besoins associés à ces transitions demeurent méconnus et peu de ressources existent. L’Association de spina-bifida et d’hydrocéphalie du Québec (ASBHQ) souhaite accompagner ses membres, leurs proches et les intervenants pour promouvoir […]

During uterine involution (occuring after giving birth), the uterus sustain diverse morphological and inflammatory changes to eliminate the potential contamination of the uterus and prepare for a subsequent pregnancy. In cows, a failure to eliminate a potential uterine contamination after giving birth could lead to endometritis, a disease characterized by persistent inflammation of the uterine […]

The project aims to understand the molecular mechanisms by which the Ankle2 protein functions to allow nuclear reformation after mitosis. This process is frequently disrupted in cancer cells, which induces an innate immune response that could be exploited in therapies. A multidisciplinary approach in the Drosophila model will be used.

Rural homelessness in Canada is still an ongoing problem that the country is trying to address. Most of Canada’s indigenous families in remote communities are living in substandard housing that needs major repairs. 3D printing of cementitious material to digitally construct building structures has already gained considerable attention from both the public and private sectors. […]

La leucémie est le cancer le plus commun chez l’enfant. Elle est déclenchée par des abbérations génétiques dans des cellules très productives dans le système hématopoïétique; ainsi, ces mutations causent une accumulation de globules blancs immatures dans le sang et les tissus. De nouveaux traitements immunothérapeutiques sont sous étude pour remplacer la chimiothérapie cytotoxique. Un […]

Durant ce stage, l’objectif est d’étudier le flux de patients entre les urgences et l’hôpital. Nous allons présenter un modèle de simulation afin d’analyser le parcours des patients dans les urgences, entre les urgences et l’admission et les urgences et le congé. Nous visons d’identifier les causes des problèmes de congestion dans les urgences retardant […]

The proposed research project would focus on the development of high-value carbon fibers from low-value waste by-products, asphaltenes, for multifunctional applications. One part of the program would highlight the efforts to scale up the technology without deteriorating the process performance. The other part of the program would focus on working with North Forge in the […]

Embedded in the surface of a virus, are different types of proteins that the virus uses to enter a host cell. These so-called viral glycoproteins are pivotal targets of the host antibody response to fight a viral infection. In recent decades, it has become clear that certain viral glycoproteins have evolved clever ways to suppress […]