Modulation of proteinase receptor 2: a novel target for cancer immunotherapy

Treatments empowering patient’s own immune system (immunotherapy) have revolutionized cancer treatment this last decade, showing substantial clinical activity in different tumor types. However, 60% of cancer patients still fail to respond to immunotherapy and other standard of care. Our laboratory recently identified the proteinase receptor 2as a new target to overcome immunotherapy resistance. We propose […]

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Sustainable Organic Waste Management towards a Circular Economy

Conventional organic waste disposal adapts a linear waste-to-discharge treatment strategy, wasting the vast amount of resources and energy embedded in organic waste. With our innovative reactor design and operation, we have demonstrated significantly increased energy and resources recovery efficiencies under loading rates higher (2 times) than reported. Our products feature high flexibility and easy operation/maintenance, […]

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Workly Law’s Startup Legal Tool Kit

The “Workly Law’s Startup Legal Tool Kit” Project focuses on product and marketing innovation in employment law and business law. This project will help the partner organization tap into the underutilized resources in the startup space, innovate and set them apart from their competition. The goal of this project is to create several innovative products. […]

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Analyzing Customer Journey

Analyzing companies’ sales data to prepare a report on what’s the best way for the company to be onboarding new customers with insights from the data and trends identified by the analysis. And to map the story of purchases that will inform the business on when/how/where customers buy products and the factors that affect the […]

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Capacity building in small and medium enterprises for sustainability change management

The TRANSFORM Project comprises a global network of researchers located in eight different countries and 11 universities. This network is committed to building the capacity of small and medium-sized enterprises (SMEs) to accelerate the transition to sustainable, resilient, and low-carbon communities. SMEs possess great potential to shape and transform the cities and communities in which […]

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Development and Optimization of Freeze-dried Formulations of Ga-68 based cold kit and its performance evaluation by Radiolabeling and Animal Imaging

The student will be involved in the research and development of a novel multi-dose lyophilized vial kit for the preparation of Gallium 68Ga-DOTATOC injection used for the PET imaging of neuroendocrine tumors. This novel kit compared to the currently available ready to use injectable solution, has better shelf life and can be easily shipped to […]

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Signal profiling of 5-HT2A receptors to develop new biased ligands

G protein coupled receptors (GCPRs) are proteins found at the surface of cells are responsible for activating numerous intracellular signaling pathways and thus are involved in regulating about every physiological response. Activation of GPCRs occurs via a diverse array of stimuli as varied as photons, lipids, ions, small hormone or neurotransmitters through to larger peptidic […]

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Development of non opioid pain therapeutics

Developing safer, more effective treatments for chronic pain has become a major area of research due to the negative side effects of opioids. This project aims to mediate the intelligent design and development of drugs, that will achieve pain relief without the detrimental side effects of addiction and respiratory depression. The proposed research will use […]

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Exploitation of special functions orthogonal on finitedomains of 2D and 3D lattices-Fourier expansions offunctions sampled on lattices

The advantages of digital data (signal functions) processing have made this technique a standard for processing real world analog data in many areas of life, from music industry to seismology. Stored digitally, the data also become less sensitive to physical limitations than their analog counterparts. Other advantages include straightforward low frequency filtering procedures (e.g. as […]

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Local in situ Controlled Delivery of Biphosphonates in Bone Metastasis

We propose to develop in collaboration with Medtronic Canada a bioceramic drug delivery system for the local controlled release of Biphosphonates (BP) – drugs that prevent bone resorption – to promote both tumor inhibition and bone regeneration at the site of bone tumor resection, eliminating the need for high systemic doses and side effects associated […]

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