Pharmacogenetic Biomarker Discovery, Personalized Medicine, and Clinical Test Commercialization in Neuropsychiatry

Pharmacotherapy is one of the primary treatments for psychiatric disorders. Given the variation in individual response, and the current trial-and-error treatment, a more personalized approach is needed. The Mitacs Elevate postdoctoral trainee will gain direct experience with all aspects of using pharmacogenetic testing to personalize medication prescriptions for patients, and the commercialization of the test. […]

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Pharmacogenetic Biomarker Discovery, Personalized Medicine, and Clinical Test Commercialization in Neuropsychiatry – Year two

Pharmacotherapy is one of the primary treatments for psychiatric disorders. Given the variation in individual response, and the current trial-and-error treatment, a more personalized approach is needed. The Mitacs Elevate postdoctoral fellow project involves the use of pharmacogenetic testing to personalize medication prescriptions for patients, and the commercialization of pharmacogenetic testing. A main component of […]

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Structural health monitoring of offshore structures using Fiber Bragg gratings

Over the last few years, optical fiber sensors have seen an increased acceptance as well as a widespread use for structural sensing and monitoring in civil engineering. FBG sensors have all the advantages attributed to the optical fibers. In addition, they can be easily multiplexed in a serial fashion along a single fiber. The experimental […]

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Small-scale Continuous Purification of Nanoparticles and Therapeutic Proteins

Our group developed a new generation of chip-based small-scale devices for continuous purification of chemicals and nanoparticles, based on the interactions of analyte with multiple types of driving forces in an electro-fluid-dynamic (EFD) system. One series of the purification devices has the electric field in parallel with the fluid flow direction (E?F), while the other […]

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Evaluation of the accuracy of the in-situ individual particle sizing technology

The research objectives are to better understand the limitations of a new particle sizing system in terms of accuracy on particle size, of accuracy on size distribution, of accuracy on particle concentration and finally of size dynamic range. During the research project, the sources of the limitations will be identified and improvements to the technology […]

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Development of Fungal-Specific Stress Response Inhibitors for the Treatment of Fungal Infections

Drug resistance of medically relevant microorganisms poses a grave threat to human health and has severe economic consequences. Fungal pathogens pose an additional complication as they are closely related to their human host. Current therapies to treat fungal infections are limited and drug resistance has already emerged in the clinic. We have conducted extensive research […]

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Impact de la représentation visuelle des recommandations basée sur l’intelligence artificielle en contexte de prise de décisions d’assortiment

Les tests utilisateurs de nouvelles générations ont recours à des technologies de pointe comme l’occulométrie, l’analyse faciale et de l’activité célébrale et capturent de précieuses informations quant à l’ergonomie et l’usage des interfaces logicielles. Ces pratiques exigent une rigueur et une précision qui obligent les différentes industries à repenser leur méthodologie de développement de produits […]

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Offshore Technology Research Program – Floating Structures

In this internship cluster, the graduate student interns will investigate relevant research topics facing the offshore industry operating in harsh offshore and ocean environments. The research topics will include the investigation of ice loads and shallow water waves, response of floating structures and dynamic positioning in harsh environments, structural integrity of vessels and structures in […]

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A novel therapeutic drug for selective treatment of castration-resistant prostate cancer with MTAP deficiency

Chemotherapy is currently the most effective approach for treatment of advanced cancer. However, chemotherapeutics do not differentiate between malignant and normal cells, and lead to serious side effects. Recent findings indicate that a substantial proportion of cancers, as distinct from normal tissue, are deficient in an enzyme called methylthioadenosine phosphorylase (MTAP). This provides a unique […]

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