Innovative Projects Realized

Explore thousands of successful projects resulting from collaboration between organizations and post-secondary talent.

30508 Completed Projects

2882
AB
5105
BC
825
MB
681
NL
860
SK
9051
ON
9491
QC
97
PE
586
NB
1141
NS

Projects by Category

Development of new classes of bio-relevant linkers for PROTACs and other conjugates using new technologies

PROTACs are bifunctional molecules that allow the elimination of target proteins in the cells. Despite the advantages of this early field, the area of small molecules PROTACs presents some drawbacks, in particular, the long and tedious syntheses of the central linker. Secondly, the variety of those linkers is quite scarce, as poly-ether or alkyl chains are almost exclusively used. Thirdly, their length variation and effects on the activity of the PROTACs are rarely studied.
The goals of this project are to develop new synthetic routes allowing the easier synthesis of various linkers, develop new categories of linkers, and combine those advances to allow the rapid synthesis of a wide range of linkers that will constitute a toolbox for next generation bioconjugates, including but not limited to PROTACs . These goals will be achieved by the use of new technologies and chemical strategies. TO BE CONT’D

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Faculty Supervisor:

André Bernard Charette

Student:

Partner:

NuChem Therapeutics

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

Université de Montréal

Program:

Elevate

Understanding the regulation of specialized metabolite accumulation in hop plants (Humulus lupulus)

Hops (Humulus lupulus) flowers are most famous for imparting the bitter taste and aroma to beer. Hop flowers produce essential oils that contain many different plant compounds, which impart the characteristic taste and aroma of hop plants. However, how the production of these oils is regulated is not fully understood. The establishment of the craft beer industry, which is also rapidly expanding throughout North America and the world, is spurring renewed interest and investment in local hop agriculture. South-western British Columbia, particularly the Fraser Valley and Okanagan regions are excellent areas for hop agriculture. The research outlined in this proposal will support the identification of the genetic factors and environmental conditions that promote the production of high quality hop flowers.

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Faculty Supervisor:

Simone Diego Castellarin

Student:

Partner:

BioCan Technologies Inc

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

The University of British Columbia

Program:

Accelerate

Conception de cellules expérimentales de terrain visant à tester des scénarios de restauration à l’aide de recouvrement isolant pour les stériles miniers d’Amaruq

Les stériles miniers sont des roches qui sont excavées lors de l’exploitation d’une mine, mais qui n’ont pas de valeur économique. Ces stériles sont disposés en empilements appelés haldes à stériles. Selon leur composition, l’eau qui s’introduit dans la halde peut en ressortir contaminée et s’écouler vers le milieu environnant. Pour empêcher la formation et la propagation des eaux contaminées, la compagnie minière doit mettre en place une méthode de restauration. Le présent projet porte sur la conception d’une stratégie pour évaluer l’efficacité d’une méthode de restauration appliquée sur les haldes à stériles en région nordique. Cette stratégie inclue la conception d’halde à stériles à échelle réduite, instrumentée et construite sur le site. TO BE CONT’D

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Faculty Supervisor:

Bruno Bussière

Student:

Partner:

Agnico-Eagle Mines (NU)

Discipline:

Engineering

Sector:

Mining

University:

Université du Québec en Abitibi-Témiscamingue

Program:

Accelerate

A novel therapeutic drug for selective treatment of castration-resistant prostate cancer with MTAP deficiency

Chemotherapy is currently the most effective approach for treatment of advanced cancer. However, chemotherapeutics do not differentiate between malignant and normal cells, and lead to serious side effects. Recent findings indicate that a substantial proportion of cancers, as distinct from normal tissue, are deficient in an enzyme called methylthioadenosine phosphorylase (MTAP). This provides a unique opportunity for developing chemotherapeutics to treat MTAP-deficient malignancies and simultaneously protect normal tissue by co-administration of 5′-deoxy-5′-methylthioadenosine (MTA), an MTAP substrate present in normal tissues. In preliminary studies we have shown that this is feasible. Here we propose to evaluate this strategy using clinically relevant, patient-derived cancer xenograft models. This approach will benefit patients with MTAP-deficient malignancies. The project will serve as a bridge between academia and the pharmaceutical industry and be beneficial for the career development of the interns in charge and may lead to new, effective cancer treatments/patents also benefiting the partner organization.

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Faculty Supervisor:

Yuzhuo Wang

Student:

Partner:

ProSafe Pharmaceuticals Inc.

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

The University of British Columbia

Program:

Accelerate

Machine-Learning-Based Artistic Photo Manipulation and Stylization on Mobile Devices

Deep Learning is the new, and fast growing bread of systems based on artificial neural networks. These are phenomenal at learning patterns and generating new pattern that have the characteristics of the data the system was trained on. One of the main artistic and creative use of Deep Learning is to process images, pictures video. One typical task is that of style transfer by which the style of one image is used to shape the rendering of the one provided by the user. While most images are taken and manipulated by mobile devices, the deep learning algorithms required for style transfer and much more are not running on these more limited mobile hardware. This project aims to change this by porting Machine-Learning-based artistic photo manipulation and stylization on mobile devices.

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Faculty Supervisor:

Philippe Pasquier

Student:

Partner:

Generate Software Inc

Discipline:

Computer science

Sector:

Information and cultural industries

University:

Simon Fraser University

Program:

Accelerate

Corrosion inhibitor for potash mining and processing plants

We propose to mitigate corrosion in potash mining and processing plants by introducing corrosion inhibitor to potash brine solutions. We will screen and formulate a cost-effective corrosion inhibitor that is compatible to potash mining and processing operation, but does not degrade quality of potash products and still provides high corrosion inhibition performance. The formulated corrosion inhibitors together with a strategy for effective inhibitor application would lengthen life span of mining and processing equipment, reduce operational downtime, increase potash production and reduce risk of injury and death of mining employees. This thus makes potash mining and processing operation safer and more economical.

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Faculty Supervisor:

Amornvadee Veawab

Student:

Partner:

Agrium;BHP Canada Inc.;Mosaic (Belle Plaine);PotashCorp

Discipline:

Engineering

Sector:

Mining

University:

University of Regina

Program:

Accelerate

Study the Mechanism and kinetics of Electrochemical Conversion of CO2 to Ethanol: A Molecular Modeling Approach

Closing the carbon cycle by utilizing CO2 as a feedstock for producing new fuels such as Methanol and Ethanol is an appropriate intermediate step towards a carbon-free future. Recently some researches on new nano-catalysts have increased the hope of bringing this technology to the market. While the reaction mechanisms are not elucidated, the present study will look at the kinetics, the structure, the energetics and dynamics involved in a model electron transfer reaction between water and carbon dioxide occurring on the catalyst. This work is thus an investigation using molecular dynamics computer simulations with results validated through experimental data. The developed methodology and the computer model can be used to define the technical specifications and to select the major components of the electrochemical reactor.

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Faculty Supervisor:

Jean-Luc Meunier

Student:

Partner:

Sigma Energy Storage Inc

Discipline:

Physics

Sector:

Professional, scientific and technical services; Utilities

University:

McGill University

Program:

Elevate

Offshore Technology Research Program – Floating Structures

In this internship cluster, the graduate student interns will investigate relevant research topics facing the offshore industry operating in harsh offshore and ocean environments. The research topics will include the investigation of ice loads and shallow water waves, response of floating structures and dynamic positioning in harsh environments, structural integrity of vessels and structures in ocean environments, safety, and marine corrosion protection of floating structures The innovative nature of this project lies in the value-added experience for the graduate students by providing them with an opportunity to work in their research area with leading oil and gas operators, classification societies, engineering firms and/or world-class research institutes. Both the company and student gain from the technology transfer and shared experiences. The internship will allow the students to develop professional skills important for their transition into the workforce after research is complete and will provide the partner company the opportunity to build….

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Faculty Supervisor:

Wei Qiu;Heather Peng;Brian Veitch

Student:

Partner:

Petroleum Research Newfoundland & Labrador;Virtual Marine;American Bureau of Shipping

Discipline:

Engineering

Sector:

Mining; Professional, scientific and technical services

University:

Memorial University of Newfoundland

Program:

Accelerate

ABHD6 as a novel drug target for obesity, non-alcoholic fatty liver disease (NASH) and cardiovascular disease (CVD)

Obesity, type 2 diabetes (T2D) and heart diseases have skyrocketed. Controlling glucose usage and insulin balance can substantially decrease the morbidity and improve the quality of life in affected individuals. Dysfunctional insulin action and energy balance in the body is associated with excessive non-adipose fat storage, particularly in the liver, and elevated circulating lipids, which contribute to heart disease. Obesity, a primary cause of T2D, is linked with white fat build-up and gradual loss of proper action of insulin. Unlike fat-storing white fat, brown fat is thermogenic, and its calorie-burning properties can reduce fat burden in the body. Increasing the brown fat function and promoting conversion of white fat to brown-like fat help lower the calorie burden and enhance insulin function and restore normal glucose usage. TO BE CONT’D

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Faculty Supervisor:

Marc Prentki

Student:

Partner:

Servier

Discipline:

Life Sciences

Sector:

Pharmaceuticals; Health and Related Sciences & Technology; Life Sciences (not health)

University:

Université de Montréal

Program:

Elevate

Detection of axial cracks in cast iron pipes using ultrasonic guided waves

Pure Technologies is a world leader in the development and application of innovative technologies for inspection, monitoring and management of physical infrastructure including water and hydrocarbon pipelines, buildings and bridges. Over the years, Pure Technologies has developed innovative, proprietary and patented technologies to provide infrastructure owners with comprehensive, state-of-the-art information. For the inspection of large diameter water pipelines, Pure Technologies has developed a platform named PipeDiver. It can be effectively deployed for long inspections on several types of pipe to determine baseline condition. Pure Technologies is interested in adding new capabilities to the PipeDiver such as the detection of axial in various configurations including bell-and-spigot joints.

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Faculty Supervisor:

Pierre Bélanger

Student:

Partner:

Pure Technologies Ltd

Discipline:

Engineering

Sector:

Utilities

University:

École de technologie supérieure

Program:

Accelerate

Optimization of Impact Diverting Membrane on Bicycle Helmet

Head Injury Prevention (HIP) Lab at Simon Fraser University in collaboration with Shield-X Technology Inc. had previously developed an impact diverting mechanism in the form of a thin multi-layered-membrane. The technology has been successfully integrated onto the exterior of a football helmet (external version) to reduce linear and rotational acceleration experienced during impact to the head. The research will focus mainly on how to adopt the technology by adding it into the interior of a single-impact helmet such as bicycle helmet without changing the exterior appearance of the helmet. A

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Faculty Supervisor:

Siamak Arzanpour

Student:

Partner:

Shield-X Technology Inc

Discipline:

Engineering

Sector:

Manufacturing

University:

Simon Fraser University

Program:

Accelerate

Impact de la représentation visuelle des recommandations basée sur l’intelligence artificielle en contexte de prise de décisions d’assortiment

Les tests utilisateurs de nouvelles générations ont recours à des technologies de pointe comme l’occulométrie, l’analyse faciale et de l’activité célébrale et capturent de précieuses informations quant à l’ergonomie et l’usage des interfaces logicielles. Ces pratiques exigent une rigueur et une précision qui obligent les différentes industries à repenser leur méthodologie de développement de produits et leur chaine de production.
L’industrie de l’édition scolaire est en pleine mutation. L’édition numérique ainsi que l’émergence des plateformes de diffusion du matériel scolaire ont modifié la manière dont le contenu de l’apprentissage est délivré à l’apprenant et impacte l’ensemble de son expérience d’apprentissage. L’étude du chercheur vise à définir comment intégrer efficacement et de manière réaliste les nouvelles générations de tests utilisateurs dans le processus de production et à recommander des outils de mesure de l’impact positif de l’efficacité de ces pratiques dans les produits d’apprentissage.

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Faculty Supervisor:

Pierre-Majorique Léger

Student:

Partner:

JDA Software Canada Ltd

Discipline:

Business

Sector:

Information and cultural industries; Professional, scientific and technical services

University:

HEC Montréal

Program:

Accelerate

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