Role of Fluid Redistribution in the Pathogenesis of Sleep Apnea

Obstructive sleep apnea (OSA) is a common respiratory disorder in adult popUlation where it

increases the mortality risk. The main treatment of OSA is continuous positive airway

pressure and although it is effective in most cases, many cannot tolerate it. Therefore, it is

important to develop new treatments for sleep apnea. We have proposed that fluid which is

accumulated in the legs during day moves towards the head when lay down to sleep. The

consequent accumulation of fluid in the neck could be a major contributor to the development

of OSA. To test this hypothesis, we aim to determine whether intravenous fluid infusion

during sleep will cause fluid accumulation in the neck, narrow the throat and induce OSA. If

so, a new approach for the therapy of sleep apnea would be to prevent fluid accumulation in

the legs during the day and its displacement into the neck at night.

Faculty Supervisor:

T. Bradley

Student:

Partner:

University of Toronto

Discipline:

Engineering

Sector:

Agriculture; Education

University:

University of Toronto

Program:

Accelerate

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