Development of Nanoparticle and Encapsulation Technology as Delivery System for Polysaccharides from Ginseng

Ginseng is a medicinal plant widely used for the treatment of various conditions, and there are two major species: Panax ginseng (Asian ginseng) and Panax quinquefolius (American ginseng). The medicinal properties of ginseng have been attributed to two main classes of chemical compounds: ginsenosides and polysaccharides (PS). We have recently developed an encapsulated PS nanoparticles (NPs) derived from American ginseng, which showed enhanced potency in protecting UV-induced skin injury in a mouse model and immunomodulatory activity in vitro. However, we have not elucidated the mechanism underlying its heightened potency. Herein, we will characterize the PS NPs, penetration of monolayers of Caco-2 cells and keratinocytes, determine the bioavailability and effectiveness after oral and topical administration in mice. PS with fluorescent tag will be prepared to track the disposition of PS materials. TO BE CONT’D

Faculty Supervisor:

Paul Charpentier;Ed Lui

Student:

Partner:

Western Phytoceutica Inc (BC)

Discipline:

Life Sciences

Sector:

Pharmaceuticals; Health and Related Sciences & Technology; Nanotechnology

University:

Western University

Program: