Imaging and spectral characterization of exosomes as carriers of Alzheimer’s Disease biomarkers in peripheral bodily fluids

We propose the development of tools that can help identify cognitively normal subjects at risk for developing Alzheimer’s Disease (AD). The tests will use small volumes of peripheral fluids (blood, saliva, urine). Our goal is to evaluate the potential of exosomes to be used as “carriers of AD biomarkers”. These markers will be essential for the assessment of susceptibility/risk for AD. We also propose to identify and develop technologies for the detection of exosomes and the AD markers they contain. Exosome isolation techniques, plasmonic-based biosensor technologies, and novel optical microscopy tools will be developed and used.

Faculty Supervisor:

Sebastian Wachsmann-Hogiu

Student:

Partner:

VIS Technology

Discipline:

Engineering

Sector:

Health and Related Sciences & Technology; Biotechnology; Nanotechnology

University:

McGill University

Program: