Multimodal imaging of EPCs in animal models using dendrimer based nanoparticle

The proposed research project is to create a nanoparticle capable of labeling stem cells to
ultimately track their localization and biodistribution in small animal models. This probe will be
unique in that it will possess multimodal imaging properties to allow visualization with
Positron Emision Tomography (PET), Single-Photon Emission Computer Tomography
(SPECT) and other clinical imaging modalities. Dendrimers are nanoparticles with a narrow
molecular weight distribution. They have tunable size and shape characteristics and consist
of a highly fundionalized surface. Through the attachment of fluorescent and radioactive
agents onto the dendrimer we hope to create a nanoparticle probe that allows maximum
imaging sensitivity without Inducing an adverse cellular phenotype. Through tllis
investigation, the partner organization will be able to investigate further clinical uses for their
radioisotopes and pharmaceuticals ..

Faculty Supervisor:

Elias Georges

Student:

Partner:

Nordion

Discipline:

Life Sciences

Sector:

Manufacturing

University:

McGill University

Program: