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One aspect of modern drug development involves understanding how enzymes function in terms of the progress of certain diseases in humans. This MITACS project involves the synthesis of small-molecule labels that can bind to a specific enzyme of interest, so as to better understand the mode of action of this enzyme as related to the progress of cancer. This work will involve the preparation of organic molecules possessing appropriate structural features that will enable selective and irreversible binding to the desired enzyme. The understanding gained as a result will enable the partner organization (Repare Therapeutics) to develop more effective treatments for cancer.
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