Using Machine Learning Software (Deep Anatomical Federated Network) to Analyze Magnetic Resonance Imaging (MRI) Sequences of Anatomical Structures

We aim to enhance AI learning of MR images by providing scans of the pectoralis major, deltoid, and gluteus maximus from young healthy adults to Deep Anatomical Federated Network (DAFNE). DAFNE is a decentralized AI software that improves over time through user refinement. Machine Learning (ML) models enable faster automated analysis, distinguishing anatomical structures and […]

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Converting colour memory to a spatial format to benefit behaviour

This project explores how the brain transforms visual information, like colour, into spatial formats when storing it in memory. Using functional MRI (fMRI), we will study how these transformations happen and which brain areas are involved. This research builds on previous studies using EEG, but fMRI will provide a clearer picture of the brain regions […]

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Analyse de l’impact du Programme de remboursement des médicaments sans promoteur de la CDA-AMC sur les décisions de remboursement et de négociation à l’APP

Ce projet vise à évaluer l’impact potentiel du programme de remboursement des médicaments sans promoteur de l’Agence des médicaments du Canada (CDA-AMC) depuis sa création, tout en analysant les conclusions des négociations avec l’Alliance pharmaceutique pancanadienne (APP). Avant l’introduction de ce programme, de nombreux médicaments étaient difficilement accessibles aux patients canadiens, car les promoteurs ne […]

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Optimization and scale up of seaweed preservation and biorefinery, and validation of bioplastic compostability

The partner, PhyCo, is a marine biotechnology startup specializing in the development of sustainable, seaweed-based bioplastics for agricultural applications. The company collaborates with the Verschuren Centre for product development, including seaweed bioprocessing and extrusion methods for seaweed-derived biomaterials. The main activity of the partner involves exploring proprietary biorefinery (multi-step extraction) technologies, developing bioplastic formulations, and […]

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Analyse du rôle et de l’impact des critères substituts dans l’homologation et le remboursement des médicaments anticancéreux au Canada.

Lorsqu’un nouveau traitement est évalué dans les études cliniques, des critères cliniques sont utilisés pour mesurer son efficacité en fonction de l’état du patient, notamment comment il se sent, fonctionne ou survit. Cependant, ces critères peuvent nécessiter un suivi prolongé avant de fournir des résultats concluants dans la recherche clinique en oncologie. Pour accélérer l’évaluation […]

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Generation of rabbit monoclonal antibodies using a microfluidic-based screening platform

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

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Generation of rabbit monoclonal antibodies using a microfluidic-based screening platform – Year two

Rabbits are increasingly recognized for their superior immune response to antigens and their ability to generate highaffinity monoclonal antibodies (mAbs) that can be used as reagents, diagnostics and therapeutics. However, methods for the discovery of rabbit mAbs are limited and extremely cumbersome. This proposal aims at developing a rapid and robust microfluidic-based approach to generate […]

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Nano-biostimulant derived from fish byproduct to improve plant growth and productivity

Global fish and seafood consumption has increased, leading to large amounts of byproducts from fish markets and processing industries. Currently, the byproducts are used to produce fish meals or dumped into the ocean, causing suffocation and introducing diseases and noxious species. Other potential uses such as bioconversion into biostimulant for agricultural use. Fish are rich […]

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High-throughput selection of monoclonal antibodies against GPCRs using a microfluidic single cell screening platform

Antibodies are biomolecules naturally produced by immune cells, called antibody-secreting cells, to protect against infection and diseases. Each antibody-secreting cell makes a unique type of antibody that binds specifically to a target molecule. A major challenge in developing antibody therapeutics is selecting the most effective antibodies from the billions produced within any given host. Our […]

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Assessing the Burden and Outcomes of Acute Respiratory Infection among Children with Medical Complexity at The Hospital for Sick Children

Given advancements in medical and surgical technology, the number of children with medical complexity (CMC) is rising. These children, who experience multiple chronic medical conditions and require ongoing specialized therapies, are at higher risk of adverse outcomes from respiratory infections. However, most research on respiratory infections among CMC has been limited by small sample sizes. […]

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Changes in Pediatric RSV Hospitalizations after the COVID-19 Pandemic, 2022-2023, Canada: An Active Surveillance Study

The proposed project will be the largest ever study of RSV associated hospitalizations to Canadian tertiary pediatric hospitals. Cases are identified via our national active surveillance program for vaccine-preventable diseases, the Canadian Immunization Monitoring Program ACTive (IMPACT). IMPACT’s pediatric hospital-based active surveillance network provides a rich source of data with rigorous quality control processes and […]

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Education in the field; using behavioral wildlife research to inform the interpretive program of an eco-tourism operation – Year two

Knight Inlet Lodge is an eco-tourism resort specializing in grizzly bear viewing, and caters to both national and international clients. The business requires research to improve their interpretive program by informing guide naturalists on the function of observed bear behaviour. Research is required to: 1) assess the relatedness and movements patterns of regularly observed bears, […]

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