Meat mass production is associated with many issues, from animal welfare, antibiotic use, climate change, destruction of ecological systems and wildlife extinction. Cultured meat industry is promising alternative to that, which offers the actual meat (not plant-based) without aforementioned issues. This project aims to contribute to development of cultured fat from a pig-derived stem cell. […]

Les aptazymes sont des molécules d’ADN ou ARN capables de prendre des conformations très particulières afin d’interagir spécifiquement avec des cibles moléculaires précises, de la même manière qu’un anticorps interagit avec son antigène. Additionnellement à ceci, les aptazymes sont capables, subséquemment à la reconnaissance de leur cible, de réguler l’expression de gènes. Avec ces puissants […]

The oncogenic kinase AKT1 is a prime therapeutic target, but its function cannot be easily researched as AKT activation in cells requires stimulation of cells with an unspecific growth factor that alters all cellular signaling. I designed a new method to deliver an already activated, phosphorylated AKT1 protein to cells that do not require the […]

Bien que des médicaments peuvent soulager certains symptômes psychotiques, ils ne sont pas suffisants à eux seuls pour mener au rétablissement des patients. L’identification et le traitement des comorbidités, dont l’addiction aux jeux vidéo (AJV), constituent une avenue prometteuse pour favoriser cette situation. Il n’existe aucune donnée concernant cette dépendance chez les patients souffrant de […]

In grain processing, milling usually plays a key role. The efficiency of the milling process is key to the profitability of the process and is decisive for the quality of the final product. However, milling is often subject to wear problems. Indeed, the degradation of the rolls varies over time depending on factors that are […]

Brain metastasis of breast cancer has a very poor prognosis in patients. Treatment options are limited because the blood-brain-barrier prevents drugs from entering the brain. Importantly, we are lacking information on how brain cells are supporting the growth of metastatic breast cancer cells. Using HER2-positive breast cancer cells isolated from a patient brain metastasis the […]

La mouche du bleuet (Rhagoletis mendax) est un ravageur d’importance dans le bleuet nain, car les fruits infestés par des larves de mouche sont invendables. La mouche du bleuet étant une menace préoccupante pour l’industrie du bleuet nain au Lac-St-Jean, notre équipe de recherche vise à développer les connaissances liées à sa biologie et son […]

The general objective of this project is to identify unbiased and objective plasma metabolomics signatures of milk and cheese consumption. We will leverage data and stored, unthawed, plasma samples from 4 high quality randomized, crossover, feeding trials (RCTs) and 1 cohort of 200 free-living adults (eMECA) that were conducted or implemented at INAF research center […]

Chinook salmon may be especially vulnerable with limited food available when they first enter the ocean and during their first winter in the Straight of Georgia. To evaluate this, researchers will use lab studies to produce a new tool, that can be used without causing harm to the fish, to see whether wild Chinook salmon […]

Au Canada comme en France, les systèmes de santé doivent faire face à un engorgement important des services d’urgence. Cette problématique majeure risque de s’amplifier dans les prochaines années. Au Québec, un essai clinique randomisé contrôlé (ECR) en cluster impliquant huit services d’urgence est mis en place. Celui-ci a pour objectif d’évaluer l’efficacité d’un nouveau […]

This research aims to develop a novel method for RNA-based regulation of gene expression, which would provide an alternative to existing popular and patented methods. The proposed method utilizes computationally designed trans-acting hammerhead ribozymes (taHHRzs), which would cleave a reporter gene transcript, unless special ‘anti-cleaver’ RNAs bind to a designated part of the taHHRz. This […]

This project consists of the first steps toward the development of a prototype of cultivated bovine meat and to produce at pilot scale. Starting from proprietary (Meatleo Inc.) bovine satellite cells, five (5) key objectives have been set: (1) To develop and validate a protocol, including a serum-free culture medium, to expand bovine satellite cells […]