Understanding blood-brain barrier dysfunction in Parkinson’s disease models

Parkinson’s disease is commonly described as a brain disorder, but recent research suggests that early events outside the brain (periphery) may influence Parkinson’s disease neuropathology. The blood-brain barrier is a structure that protects the vulnerable brain tissue from blood-borne toxins and circulating immune cells, but barrier function appears compromised in PD. A consequence, there may […]

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Prediction of RNA splicing changes from genetic variations is high-risk cancers

Pancreatic cancer is the third leading cause of cancer death in North America. Because pancreatic cancer is hard to treat and is often diagnosed at a late stage, patient survival is often measured in months. Current treatments consisting in chemotherapy and surgery are not effective. However, new therapies referred to as “immunotherapies” that leverage the […]

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How does the orthographic transparency of their first-language impact second-language learning in university students with and without dyslexia?

In today’s multicultural world, learning new languages has become essential for students’ academic, personal, and professional development. Skilled reading requires the coordination of visual, phonological, and broader cognitive skills, which may create unique language specific challenges. This project examines first- (L1) and second-language (L2) reading profiles in university students with and without dyslexia, focusing on […]

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Fear-avoidance, function, and infrared thermography in injured professional football players

Chronic pain is one of the most common and debilitating conditions worldwide, placing a significant burden on healthcare systems. (1) In musculoskeletal injury rehabilitation, fear-avoidance beliefs—where athletes avoid movement due to fear of pain or reinjury—are strongly associated with greater pain, reduced function, and prolonged recovery. (2) Yet, this psychosocial dimension has yet to be […]

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Neuroinflammatory and Neuroimmune Mechanisms Linking Migraine and Multiple Sclerosis: A Systematic Review of Human and Animal Studies

This project will examine the connections between migraine and multiple sclerosis (MS), two common neurological conditions that affect millions of people worldwide. While migraine causes severe headaches and MS can lead to long-term physical and cognitive challenges, research suggests that these conditions may share underlying immune and inflammatory mechanisms. By systematically reviewing existing human and […]

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Efficacy and Safety of Nanobody-Based Interventions Targeting Amyloid-ß and Tau aggregates in Alzheimer’s Disease: A Systematic Review

This project, conducted in collaboration with TÉLUQ University, aims to systematically review and evaluate the efficacy and safety of emerging nanobody-based therapies designed to target amyloid-ß and tau aggregates—the two hallmark proteins implicated in the development and progression of Alzheimer’s disease. Nanobodies, due to their small size, high stability, and strong binding specificity, represent a […]

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Antibody engineering and DNA origami nanodelivery strategies for targeted melanoma cancer therapy

This project aims to develop a new targeted strategy to deliver therapeutic molecules specifically to melanoma cells, a type of skin cancer known for its aggressiveness and resistance to current treatments. The approach combines engineered single-chain antibodies (scFvs) that recognize unique markers on melanoma cells with nanopyramids synthesized using DNA Origami, capable of transporting cytostatic […]

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Validation of the tissue regenerative properties of a novel peptide using a cellular co-culture model

This project addresses untreated dental caries, the world’s most prevalent disease affecting over 2 billion people, particularly underserved populations. The research will validate a novel peptide therapeutic that simultaneously promotes dental tissue regeneration and controls inflammation in infected tooth pulp. Using advanced cellular co-culture systems that mimic the inflammatory environment of dental infections, the study […]

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