Le cancer de la bouche fait partie de la maladie maligne du carcinome épidermoïde de la tête et du cou, qui constitue un grave problème de santé publique en raison de son incidence, de sa prévalence et de sa mortalité élevées (Moro JDS et al., 2018). Il est classé au 6e rang mondial des tumeurs […]

Les instruments de mesure (questionnaires) qui sont complétés directement par les personnes permettent une évaluation en adéquation avec le vécu et les expériences de ces personnes. De tels instruments de mesure nécessitent cependant une évaluation approfondie par des experts afin d’assurer la validité du contenu des questions et l’association des questions avec le phénomène qu’il […]

The p53 protein plays a major role in cancer prevention, and over 50% of cancer diagnoses can be attributed to mutated p53. The main function of p53 is to prevent uncontrolled growth of damaged cells and inhibit tumour formation. Mutant p53 has provided a unique opportunity to design multifunctional molecules that act on different aspects […]

The Senegalese sole is an important species of flatfish in the ecology of coastal ecosystems in southern Europe and North Africa and a staple food source for human consumption throughout its range. It is also a species of great interest for studies of retinal structure and function as it possesses unique photoreceptor distributions that are […]

Imaging of cerebral perfusion (the delivery of blood to a capillary bed in the brain tissue) is significant for diagnosing a variety of diseases. There are multiple challenges associated with perfusion imaging which significantly limits the quality of cerebral perfusion images. I am planning to develop a novel approach of cerebral perfusion magnetic resonance imaging […]

Individuals with post-traumatic stress disorder (PTSD) often struggle to relax, or simply be at ‘rest.’ In particular, recent research has revealed participants with PTSD show hyper-activity across the visual cortex while at rest. Referred to as sensory hyper-activity and disinhibition, altered resting-state patterns are thought to be underlying hypervigilance and re-living sensations clinically, as well […]

The intestinal microbiota is essential for enhanced gut health and adequate fiber digestion. Factors such as diet transition and the stress of parturition are associated with changes in the normal microbiota of cows. Microbiota manipulation to improve performance can be achieved by the use of feed additives, such as and essential oils and vitamins, but […]

During surgery, a neurosurgeon must refer to three levels of image information: macroscopic from the patient’s MRI or CT, providing anatomical context of the surgical target; mesoscopic information from a surgical microscope or exoscope providing a highly magnified view of the region surrounding the surgical target; and the most important microscopic information provided by histology […]

During surgery, a neurosurgeon must refer to three levels of image information: macroscopic from the patient’s MRI or CT, providing anatomical context of the surgical target; mesoscopic information from a surgical microscope or exoscope providing a highly magnified view of the region surrounding the surgical target; and the most important microscopic information provided by histology […]

Many studies suggest that genes, environment, and age contribute to the onset of late-life neurodegenerative disease like amyotrophic lateral sclerosis. Epidemiological studies have shown correlations between environmental chemical exposure and neurodegeneration, but no direct and causal relationships have been established. Conversely, there may be environmental actors that suppress or delay neurodegeneration outcomes. The human body […]

Many studies suggest that genes, environment, and age contribute to the onset of late-life neurodegenerative disease like amyotrophic lateral sclerosis. Epidemiological studies have shown correlations between environmental chemical exposure and neurodegeneration, but no direct and causal relationships have been established. Conversely, there may be environmental actors that suppress or delay neurodegeneration outcomes. The human body […]

Cytokines are proteins that can modulate cellular activity by binding to membrane-bound receptors or soluble receptors. When a cytokine binds to a soluble receptor, it follows the trans-signaling pathway. This signaling pathway induces unique effects on cellular activity which can drive disease progression. This proposal describes the development of a cell-based assay that can be […]