Fish use of restored and natural salt marshes in Maritime Canada

Salt marshes are coastal wetlands that provide many ecosystem services. Many fish species are known to use salt marshes as habitat at some point throughout their lives including those that hold commercial and recreational value. Depending on their location, salt marshes may experience varying degrees of tidal flooding, not only making more areas of the […]

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Comprehensive Molecular Analysis of Pre- and Postmenopausal Human Mammary Cells to Enable Their Optimized Growth as Organoids Ex Vivo

The goal of this project is to discover new factors essential for maintaining a normal human mammary gland. The approach is to generate and analyze in depth the protein-encoding RNAs and chromatin states that control their expression in the different types of cells that constitute the human mammary epithelium and its surrounding stromal cells. This […]

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Comprehensive Molecular Analysis of Pre- and Postmenopausal Human MammaryCells to Enable Their Optimized Growth as Organoids Ex Vivo – Year two

The goal of this project is to discover new factors essential for maintaining a normal human mammary gland. The approach is to generate and analyze in depth the protein-encoding RNAs and chromatin states that control their expression in the different types of cells that constitute the human mammary epithelium and its surrounding stromal cells. This […]

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Development of a specific targeted therapy for hepatocellular carcinoma

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseases such as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer […]

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Development of a specific targeted therapy for hepatocellular carcinoma – Year two

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseases such as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer […]

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Mass spectrometry for multiplexed highthroughput analysis of large molecules

Whether it is for research, development or diagnostics, life sciences typically require the quantitation and characterization of samples with assays that classically measure molecules one at a time. Considering that the development and execution of such assays are time consuming and requires considerable investment, the uses of multiplexed analysis would be highly advantageous. Mass spectrometry […]

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Characterizing anti-inflammatory properties of medicinal mushrooms

Medicinal mushrooms possess compounds with beneficial properties, including anti-microbial, anti-tumoral, and anti-inflammatory, which support their role and application in current healthcare practices. In this proposal, we will measure the impact and role of extracts from medicinal mushrooms provided by Wake Network Inc. to identify how immune cells and an animal model change their response to […]

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Optimization of Graphical User Interface for the Digital Pathology Workstation

The workflow of pathologists will soon be revolutionized with the introduction of digital pathology allowing pathologists to view tissue samples as a digital image on a computer workstation. Such a conversion from traditional microscopy will bring many benefits to the pathologist’s workflow aiming to boost significant efficiency as well as ergonomic benefits. However, much work […]

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Assessing hatchery related well-being of leghorn chicks

Most Canadian poultry originate at commercial hatcheries. Recently hatcheries have had concerns about chick welfare brought to their attention. Very little research has been performed that looks at the welfare of chicks at the hatchery or during transport to farm. During the proposed research project, the intern will look at three events that happen to […]

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Improving protein content in rice grains through prime editing

Protein deficiency is a major problem affecting large scale of the world’s population. Rice, the globally desired staple food, has low protein content (7-10%) in its grains. Though rice protein content is low compared to other cereals, it is highly desired due to the presence of highly nutritious and easily digestible glutelin protein. Grain Protein […]

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Post-breeding and migration movement of adult and juvenile songbirds among protected areas in eastern Georgian Bay, Ontario

The coasts of Georgian Bay (Lake Huron) are used extensively by migratory songbirds (including species at risk) for both breeding and migratory fueling. We will study how adult and juvenile songbirds use and move among islands and the mainland during the post-breeding period when juveniles are still developing and adults moult flight and body feathers. […]

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Use of AI and Wearable Data for Public Health Monitoring

In this proposed project, our research team aims to develop a data ecosystem to use consumer-level technologies such as fitness trackers and wearables to support public health decision making. We will use the COVID-19 pandemic as a testing scenario for the technology, exploring the data to improve our understanding of the impact that social-isolation had […]

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