Selon les théories développementales du risque suicidaire, les évènements précoces (début de la vie) peuvent avoir un impact considérable sur le risque suicidaire à long terme. Ce projet contribuera à la compréhension de l’impact des facteurs précoces sur les comportements suicidaires à l’adolescence en utilisant des techniques novatrices de machine learning sur les données de […]

Canada is among the world’s largest producers of energy derived from resource extraction. Canada’s Oil Sands Region produces 70% of Canada’s crude oil, and ranks third, after Saudi Arabia and Venezuela, in terms of proven global crude oil reserves. In order for Canadian industry to continue to meet this high demand for energy they must […]

The study the nervous system using brains that people donate to science after they die is called ex-vivo study. The microscopic study of ex-vivo brains allows to understand the structure of a given region. However, we cannot study the brain of healthy living people (in-vivo) using microscopy. One method to study the brain in-vivo is […]

Multiple antibiotic resistance has increased over the past decades, challenging our ability to treat bacterial infections and thwarting our ability to develop new antimicrobial agents. Many resistance genes have not evolved within the pathogenic isolates but were acquired by lateral transfer. We recently showed that genes conferring glycopeptide resistance are highly prevalent in the human […]

Vaccine antigen production is a process that entails numerous variables. In order to have a consistent and robust process, monitoring of process parameters and controlling output variables within a certain range is the best practice. To accomplish this objective, analytical tools are used, on-line, off-line, at line. Real time monitoring of the processes is advantageous […]

Changes in the intestinal microbial composition (dysbiosis) during development have an impact on the progression of neuro-inflammatory and neuronal degenerative disorders. Probiotics have been shown to reduce these effects. However, the current literature lacks research on intestinal dysbiosis during the maturation of the intestine and the brain and does not recognize the sexual dimorphism of […]

Tourism, nature-based recreation and residential development within the Bow Valley (BV) of Alberta’s Rocky Mountains are all valued and continually increasing. The BV is also important for large mammals as it provides habitat for iconic species like grizzly bears to live in and move through. The Yellowstone to Yukon Conservation Initiative (Y2Y) is dedicated to […]

Prescribers rely on guidelines for appropriate use and prescribing of opioids. Currently, there are no risk prediction calculators available to quantify the risk of prescribing an opioid that uses a patient’s history and drug utilization pattern. Machine learning algorithms offer an opportunity to perhaps develop such a risk calculator as a result of the large […]

The cellular clearance pathway autophagy is required for degrading toxic proteins and damaged organelles, but is disrupted in many neurodegenerative diseases. During induction many autophagy regulators quickly localise to membranes from the cytosol. The Martin lab has identified palmitoylation, which involves the addition of the fatty acid palmitate to cysteine residues, as a potential regulator […]

Pulmonary arterial hypertension (PAH) is a progressive condition characterized by the chronic elevation of pulmonary artery (PA) pressure leading to failure of the heart. In spite of recent advances in approved therapies, PAH remains a serious disease with significant mortality. In contrast to the earlier belief that contraction of pulmonary vessels played a key role […]

This project is aimed at disentangling the root and rhizospheric soil microbiomes in order to develop bioinoculants as biofertilizers and biocontrol agents for improved productivity and health of black pepper instead of using agrochemicals. This new green product will lead certified organic black pepper, a better environmental and human health.

The temporary maintenance of information is known as working memory, and it enables behaviour that we take for granted, such as remembering a phone number or avoiding an obstacle after turning off the lights. Despite its importance for everyday behaviour, the neural mechanisms underlying working memory are/remain unclear. While some single-neuron recordings in monkeys correlate […]