Voies de signalisation des cellules ciblées par un nouvel analogique de curcuma et Anethole et son possible amalgamation avec des traitements de chimiothérapie et de radiologie dans le cancer buccal

Le cancer est un problème de santé mondial et la deuxième cause de décès la plus courante chez les humains. Selon des statistiques récentes, il y avait plus de 18 millions de cas actifs de cancer responsables d’environ 9,6 millions de causes de mortalité. (OralcancerfoundationFacts) Selon la Fondation du cancer buccal, les tumeurs malignes de […]

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Wearable Technologies for Inferring and Enhancing Vestibular Balance Function

The vestibular organs detect head movement and are involved in the coordination of standing balance. With balance problems being a common and expensive healthcare cost internationally, there is a growing need for new diagnostic and therapeutic medical devices that target vestibular balance function. In particular, a wearable device that could be used outside the clinic […]

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Antimicrobial activity of Kisameet Clay

The problem to be addressed is if detailed laboratory studies can be designed out to confirm and extend the historical, anecdotal information on the therapeutic/medicinal properties of Kisameet clay (KC). There is much non-scientific information alleging the potent antimicrobial activities of many clay products. In this research proposal we propose to carry out a detailed […]

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‘Assembling and investigating Tl-201 radiolabelled texaphyrin nanoparticles targeted to prostate cancer cells for Auger electron radiotherapy’

Thallium-201 (Tl-201) is mostly known to clinicians from its previous use in diagnostic imaging. However, this radionuclide is also a potent Auger electron emitter, releasing around 21 short range, low energy electrons per decay. Auger electron emitters have a potential in targeted treatment of small tumours due to localised energy transfer. So far, Tl-201 therapeutic […]

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Sleep and circadian rhythms phenotyping in high-risk bipolar offspring

Bipolar disorder (BD) is a chronic psychiatric disorder with peak age of onset between 15 and 25 years. In clinical practice it takes over a decade from initial symptom presentation to accurate diagnosis, with such delays being linked to a range of adverse consequences. Therefore, finding early markers of vulnerability is essential. Familial history (i.e. […]

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Scaling-up restorative assisted evolution on Anthropocene coral reefs

Global mass coral bleaching events caused by marine heatwaves are becoming ever more frequent under climate change. Without action, the socio-ecological services provided by coral reefs may be lost. Active management interventions may be required to support the resilience of future coral reefs. The CORALASSIST Lab (UK) is testing assisted evolution in Palau: selective breeding […]

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Selection for antimicrobial resistance by plant protection products – analysis of established experimental field sites

Antibiotics are applied to agricultural plants and soils as plant protection products (PPPs) to combat bacterial disease. Their use in agriculture has the potential to cause development and spread of antibiotic resistance genes. Non antibiotic PPPs such as herbicides and insecticides are also applied to agricultural soils. There has been limited research into whether non […]

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Using genetic variants as a treatment decision aid for the optimization of antipsychotic treatments: a critical appraisal of the literature.

The group in Canada has extensively studied the factors (known as biomarkers) that can influence how people respond to anti-psychotic drugs, including if patients will develop side-effects. Our group in Liverpool has experience with compiling and analysing the large amounts of evidence required to prove a link between the biomarkers, and the patient’s response. The […]

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Predicting life history traits for data-poor ray species

Fisheries are the main global threat to elasmobranchs (sharks and rays). Elasmobranchs commonly display conservative life history traits (slow growth, long life, late sexual maturity and low fecundity), making them extremely vulnerable to non-natural mortalities. However, there is significant variation, with some species exhibiting life history traits more resilient to exploitation. In order to assess […]

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Impacts of warming on boreal peatland microbial community structure and function

Peatlands, a type of wetland containing a thick organic layer of partially decayed plant material, are the largest terrestrial carbon stocks. Climatic changes, including warming, could result in a lowering of the water table in peatlands, increasing oxygen availability to microbes and mesofauna allowing faster break down of the organic material and consequent release of […]

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Exploring the Risk Factors for Sequential or Concurrent Dengue and Zika Outbreaks in a Naïve Population

Arboviruses pose an ever-growing concern as the habitat of vectors expand alongside climate change. The outcome of outbreaks is often heavily influenced by the immune status of the population. Different pathogens can either protect against others or increase susceptibility and morbidity depending on infection timings and how closely related the pathogens are. A good example […]

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