This project will result in the expansion of an athlete-focused genetic test to include additional genetic markers and algorithms for the purpose of personalized caffeine advice for endurance and other forms of exercise (strength, power, anaerobic-power) through continued analysis of 23 caffeine-associated genes that affect an athlete’s response to caffeine (positive, negative or no effect). […]

This project will result in the expansion of an athlete-focused genetic test to include additional genetic markers and algorithms for the purpose of personalized caffeine advice for endurance and other forms of exercise (strength, power, anaerobic-power) through continued analysis of 23 caffeine-associated genes that affect an athlete’s response to caffeine (positive, negative or no effect). […]

Molecules possessing a carbon-phosphorus bond (C-P) have traditionally been considered rare in Nature. For example, there are only ~50 phosphonate natural products known, although several have achieved commercial success (e.g. the antibiotic fosfomycin). In addition, several phosphonate cell surface modifications have been found over the last half century, but nothing is known regarding their biosynthesis […]

The proposed project includes 2 objectives: (1) provision of high quality evidence on the effect of specific food sources of sugars on cardiometabolic risk factors by conducting multiple systematic reviews and meta-analyses (SRMAs), to address the effect of replacing sugar-sweetened beverages with either diet pop or water in a randomized controlled clinical trial, and to […]

The proposed project includes 2 objectives: (1) provision of high quality evidence on the effect of specific food sources of sugars on cardiometabolic risk factors by conducting multiple systematic reviews and meta-analyses (SRMAs), to address the effect of replacing sugar-sweetened beverages with either diet pop or water in a randomized controlled clinical trial, and to […]

The 24-hour light-dark cycle dictates the organization of life in most species on this planet. Internal timekeepers, so called circadian clocks, help to anticipate recurring daily changes and orchestrate the body’s physiological functions accordingly. In mammals, the core clock resides in the suprachiasmatic nucleus (SCN) and is synchronized by light. The SCN projects to several […]

This program is to analyze the regulation of cell cycle progression and the mechanism of chromosome segregation with regard to Kinesin5 and Kinesin8 families. Defects in these processes can result in the formation of aneuploid cells, a hallmark of many solid cancers. Thus, insights into the function and regulation of Eg5 and Kif18A (one protein […]

Roughly 4-6% of the general population suffers from excessive daytime sleepiness. Central hypersomnolence disorders are characterized by incurable constant occurrence of this daytime sleepiness in combination with a disturbed sleep-wake cycle, resulting in severely impaired daytime functioning. Central hypersomnolence disorders are normally diagnostically divided in two types of narcolepsy and idiopathic hypersomnia. While narcolepsy type […]

Crop losses and the economic impact caused by canola insect pests is substantial, depending on outbreak conditions. With the predicted de-registration of two key insecticides, canola producers are potential subject to greater economic losses. Entomopathogenic nematodes (EPNs), also known as predatory nematodes, are commercially available biocontrol agents for the management of insect pests. Although below-ground […]

The development of cellular therapeutics is acutely dependent on the ability to evaluate the functional characteristics of the cells in predictive animal models. This forms the basis of key pre-clinical data packages that are key for regulatory submissions preceding human clinical trials. The development of appropriate model systems, the execution of the surgical techniques to […]

The development of cellular therapeutics is acutely dependent on the ability to evaluate the functional characteristics of the cells in predictive animal models. This forms the basis of key pre-clinical data packages that are key for regulatory submissions preceding human clinical trials. The development of appropriate model systems, the execution of the surgical techniques to […]

Diabetes mellitus, a common metabolic disorder, exhibits neuropathic complications that can eventually lead to disabling pain (Todorovic 2015). This is attributed to hyperglycemia/high glucose resulting in neuronal hyperexcitability (Todorovic 2015). Importantly, diabetes-evoked neuronal hyperexcitability and neurotoxicity can be caused by alterations in voltage-gated sodium channel (VGSC) expression (Hong, Morrow et al. 2004), resulting in changes […]