Diabetes mellitus, a common metabolic disorder, exhibits neuropathic complications that can eventually lead to disabling pain (Todorovic 2015). This is attributed to hyperglycemia/high glucose resulting in neuronal hyperexcitability (Todorovic 2015). Importantly, diabetes-evoked neuronal hyperexcitability and neurotoxicity can be caused by alterations in voltage-gated sodium channel (VGSC) expression (Hong, Morrow et al. 2004), resulting in changes […]

Stroke is the most frequent neurological disorder leading to long-term disability by an impairment in movement control. In this project we aim to quantify the damage to a patient´s brain with a newly developed method: Tractography-based Lesion Assessment Standard (TractLAS). This tool provides a patient-specific quantification of the whole-brain structural network damage caused by stroke. […]

Estimates of population size and structure of the Davis Strait polar bear population are uncertain due, in large part, to the prohibitive costs of conducting regular aerial surveys. In recent years, Inuit have indicated that increased bear abundance has resulted in public safety concerns. In addition, Inuit believe that polar bears have negatively impacted other […]

Estimates of population size and structure of the Davis Strait polar bear population are uncertain due, in large part, to the prohibitive costs of conducting regular aerial surveys. In recent years, Inuit have indicated that increased bear abundance has resulted in public safety concerns. In addition, Inuit believe that polar bears have negatively impacted other […]

ImmunoBiochem is developing novel anti-cancer therapeutics to address unmet need in intractable solid tumors. Because solid tumors are highly heterogeneous and evasive, recognizing cancerous cells, while avoiding damage to normal tissue, is a challenge. As a result, many targeted therapies quickly come up against resistance, resulting in patient relapses. ImmunoBiochem is solving the issue of […]

The immune system has evolved a diverse array of tools to detect and eliminate foreign pathogens from the body. Bacteria too have evolved methods to interfere with the immune system’s ability to detect them. This allows bacteria to be able to replicate and cause a longer illness. Our project looks to find out how the […]

A certain number of newborn babies may suffer from infection. Many of such infections go unnoticed but may have negative effects on child’s health. There is currently no satisfying means to detect such babies early on. We have learned that using information contained in fetal heart beats we might better predict if a yet unborn […]

Public health concerns about the impact of antibiotic use on antimicrobial resistance has challenged the current use of antibiotics in broiler chicken. For this reason, the Chair in Poultry Research of the Université de Montréal led a large-scale project in the province of Quebec to study the impacts of antibiotic reduction strategies on broiler chickens’ […]

While the effectiveness of early psychosis interventions (EPI) for young people with first-episode psychosis has been well-established, research suggests that almost one-third of patients disengage from services. Although lack of family involvement and substance use have arisen as consistent factors associated with EPI disengagement, many other factors remain unexplored. Furthermore, few studies have explored patient […]

While the effectiveness of early psychosis interventions (EPI) for young people with first-episode psychosis has been well-established, research suggests that almost one-third of patients disengage from services. Although lack of family involvement and substance use have arisen as consistent factors associated with EPI disengagement, many other factors remain unexplored. Furthermore, few studies have explored patient […]

Traditionally, forest plantation management practices in Central America have revolved around clear-cut management and the use of a single, exotic tree species. While these practices simplify the management and planning of plantations, they often leave much to be desired when considering overall environmental impacts. The goal of this study is to determine how a tropical […]

Childhood Trauma (CT) is considered to be an important environmental risk factor for schizophrenia. Exposure to childhood trauma can cause immune system disorders, which affect the early development of the central nervous system and the susceptibility to schizophrenia. However, the mechanism of CT is unclear. Genes can be regulated through the activity of several noncoding […]