Metabolite pathway mapping in Euglena: A strategy for predictable product optimization

Noblegen Inc. is an advanced bioproducts manufacturer dedicated to developing cost-effective, naturally-derived biomaterials and biochemicals for a wide range of consumer and industry sectors. We employ a unique organism, algae, to continue to do what it does naturally – decontaminate wastewater sustainably and affordably while also generating valuable biomass for use in biomaterials and biochemicals […]

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Apply Deep Neural Network to Detect Malignant Lung Nodules in CT Scans

Lung cancer has a poor prognosis and a high incidence in low resource settings. Early detection of malignant nodules can enable prompt intervention and improve treatment outcomes. Despite the recognized benefits of early nodule detection, it is clinically and computational challenging. Convolutional neural network (CNN) is a type of machine learning that has been applied […]

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Encapsulation of cells in a biocompatible hydrogel to relieve pain following intervertebral disc degeneration

Intravertebral disc degeneration is a common debilitating condition for which there is no cure and leads to back pain and disability. In order to provide sustained pain relief, research is investigating the use of local cell transplantation into the disc. However, many current cell delivery strategies suffer from low cell retention and survival following injection […]

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Parallel implementation of the variant calling process using the UPMEM technology

Organisms have enormous amounts of instructions encoded in their DNA. When DNA sequences are found using sequencing methods, such as New Generation Sequencing, they are stored as very large datasets. Merely knowing the sequence of an organism’s DNA is not enough, however, and there needs to be further processing of the datasets to extract meaningful […]

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Development of forest legacy-based mine reclamation techniques for recolonizing the soil food web and promoting vegetation establishment

The August 2014 tailings dam breach at the Mount Polley Mine, BC severely disturbed downstream forest ecosystems through erosion and tailings deposition. The impacted area presents an opportunity to research using ecosystem legacies (components that survive a disturbance) to rehabilitate disturbed sites. A field trial at Mount Polley is testing seedling establishment and soil food […]

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Beneficial microbes and fishes of the Amazon: a story of co-adaptation to the extreme conditions of the most biodiverse freshwater ecosystem on Earth, the black waters of the Amazon basin

The Earth’s richest freshwater fish fauna is found in the Brazilian Amazon basin. This resource represents the primary protein source for the “ribeirinhos”: the populations of native Brazilian fisherman living in the upper Amazon. The black waters of the Amazon River are poor in nutrient, ion, oxygen and are acidified by humic acids from surrounding […]

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Using hyperpolarized 13P MRI measure in vivo pH of the placenta

Placental dysfunction is the leading cause of stillbirth, and assessment of fetoplacental health in utero is limited. Our goal is to use MRI to gain functional information of the placenta, specifically to measure pH as a critical indicator of placental health. Current methods of this use 13P MRS but are challenged by low signal-to-noise ratio […]

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Sustainable production of cellulosic ethanol from pretreated sugarcane bagasse using ruminal fluids extracted from ruminating animals

Increase in global temperatures, over dependence and depletion of fossil fuels to fulfill the human needs have forced the mankind to produce sustainable bioenergy. Plant biomass which contains lignocellulose polymers constitutes the most abundant components on the earth’s surface. Naturally, enormous amounts of cellulose are digested by the cattle and this process of digestion is […]

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Physiological signal based interface for a robotic system to support play in children with physical disabilities

Through play children develop sensory, motor, cognitive, communication and social skills. Children with physical disabilities, who have a limited access to play, may experience negative impacts on these aspects of development. Using robots to manipulate play objects can contribute to the children’s independence, social and cognitive development. The interface with which the children control the […]

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Use of non-invasive wildlife detection data to identify habitat of importance to focal species in a conservation and forestry matrix

Understanding how many animals live in a given area, and how those animals move from one place to another, is centrally important for properly conserving and managing landscapes. This project aims to study grizzly bear populations in the Great Bear Rainforest of British Columbia, BC. It will use DNA data collectively non-invasively from grizzly bears […]

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Development of new therapeutics for castration-resistant prostate cancer treatment

Castration-resistant prostate cancer is a late stage disease and many people die of it due to lack of effective therapeutic drugs. In the current project, we propose to develop new therapeutic drug a to specifically target CRPC’s common weak points, which are MCT4 and eIF4E gene’s proteint products that play very important roles in regulation […]

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