Understanding the Impact of Legal Cannabis Access on Health: A Large, Prospective Cohort Study of Canadians Obtaining Medical Cannabis Authorization

Although legal access to medical cannabis has been available in Canada for many years, our society has yet to fully understand the important health implications surrounding the use of medical cannabis or recreational users. However, the current availability of medical cannabis in Canada means that researchers have access to a large number of individuals who […]

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Importance du frêne pour la biodiversité dans les forêts ripariennes sous influence du castor et de l’agrile du frêne

Depuis l’arrivée de l’agrile du frêne en Amérique du Nord, et plus particulièrement suite aux reportages sur les ravages de cet insecte exotique au niveau des arbres dans les villes, nous sommes plus vigileants lorsque les nouvelles traitent des frênes. Une large proportion des gens connaissent néanmoins peu lesrôles écologiques des frênes, et il est […]

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Effects of exotic invasion and terrestrial DOC on aquatic food web quality, and the body condition and Hg bioaccumulation of sportfish

The project will quantify spatial variation in food web quality associated with round goby / dreissenid mussel invasion and terrestrial dissolved organic carbon to understand how it may mediate the nutritional state (fatty acid content), body size, and Hg contaminant load of sportfish. We will work across existing spatial aquatic gradients in historical inorganic Hg […]

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Functional specific IgG4 and basophil activation during standardized house dust mite specific immunotherapy

Specific immunotherapy (SIT) refers to a treatment that controls allergic symptoms by improving the patient’s tolerance by administering gradually increasing doses of allergen extract. The mechanism of SIT is very complicated. Preliminary research showed that immunoglobulins are elevated in patients after SIT, and the increase in immunoglobulin sIgG4 is positively correlated with improvement of clinical […]

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In vivo evaluation of smart nanocarriers for cancer therapy

Cancer is the leading cause of death worldwide. Despite of development of arsenal of medications to treat cancer, the efficiency of marketed medications has been drastically compromised by their unwanted and uncomfortable side effects. To address this problem, we have developed new nano-sized drug transportation carriers to deliver the drugs to the tumor tissue and […]

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Determining the effects of gating modifier compounds on cultured central nervous system neurons as potential therapeutics against epilepsy.

Voltage-gated sodium channels are key contributors to excitability in living organisms; hence, modulation of these channels through mutations and/or environmental triggers can often lead to serious disorders. Having an enriched understanding of the sodium channel electrophysiology may result in uncovering potential therapeutic targets. The general aims of our research include studying the effects of various […]

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Drug loaded co-polymeric nanoparticles as targeted delivery systems: Preparation and evaluation

The research project deals with the development of a targeted drug delivery system for cancer treatment. This drug delivery system features the use of nanoparticles (NPs) as efficient carriers for cancer drugs. Current cancer therapy regularly involves the use of chemotherapy to kill cancer cells; however, chemotherapy affects normal healthy cells and patients may experience […]

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Development of plant-based beverage with high content and quality proteins.

Plant-based beverages are inappropriate alternatives to bovine milk, due to lower protein content and not sufficient amount of essential amino acids. To produce nutritionally complete plant-based beverage with high overall acceptability, the technological interventions and fortification techniques need to be developed. Oat is one of the promising raw material for preparation of functional plant-based milk […]

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Evaluation of probiotic bacterial strains for enhanced microbial biotransformation of polyphenol-rich potato extract

The proposed project searches to understand the effect of probiotic bacterial strains belonging to the Lactobacillus and Bifidobacterium genera on the degradation and bioavailability of phenolic compounds present in potatoes (Solanum tuberosum L.) after in vitro digestion. The more easily absorbed metabolites are associated with protective effects against cancer and diabetes mellitus type II. Additionally, […]

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Designing quality control strategies to assess the self-assembly and biological stability of chitosan nanoparticles

In this grant, the consortium will develop new methods to characterize nanoparticles prepared with a proprietary polymer. This study will enable the fabrication and characterization of better performing nano-sized particles encapsulating therapeutic molecules, commonly called nanomedicines. This study will allow to monitor how the polymers self-assemble into nanoobjects under different conditions, and to study how […]

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