Providence Healthcare has established a reputation as one of the leading centres for cardiovascular research and treatment in Canada. Providence Healthcare and AstraZeneca, a research-based pharrnaceutical company, are interested in furthering science and irnprove patient outcomes. The purpose of this study is to determine the best method of long term follow up for patients with […]

The project aims to validate the effectiveness of “phase contrast” synchrotron (x-ray) imaging techniques in detecting very small-scale features (particularly amyloid plaques) commonly associated with the onset of Alzheimer’s disease. This will be done though comparison of synchrotron-generated images of Alzheimer-afflicted brain tissue, against their optical microscopy image counterparts. The experimental process will involve five […]

La résistance aux antibiotiques continue de s’accroître à travers le monde et devient inquiétante. Clostridium difficile est une bactérie multi-résistante responsable de nombreuses maladies intestinales pouvant être fatales. En raison des graves symptômes causés par les infections à C. difficile, la qualité de vie des personnes atteintes se trouve grandement réduite. Ces infections sont complexes […]

This project is based on the development of a new spatiotemporal release system for combination of active principle ingredients (API) under mechanical stimuli. The therapeutic schemes for some pathologies is based on the use of combined drugs to improve the efficiency or reduce the risk of resistance (cancer, infection treatments). Moreover, the use of hydrogels […]

Proper functioning of astrocytes and of the endocannabinoid system in the hypothalamus has been strongly linked to feeding behaviour and energy balance in mice. Furthermore, a strong molecular link has been found to connect cannabinoid receptors to leptin (a hunger hormone) receptors in hypothalamic astrocytes. Specifically, deletion of cannabinoid receptors in hypothalamic astrocytes disrupted the […]

Septic shock is an acute pathology that is the leading cause of admission to ICUs across Canada, and the developed world. Unfortunately, no treatment to date has yet to be proven beneficial. Cardiac failure is a major factor in the mortality induced by septic shock. A major player to be targeted in treating this dysfunction […]

Some biochemical processes are challenging to be studied due to the number of components that they are comprised. Splicing is a challenging process that involves removal of unnecessary information from messenger RNA for synthesis of a protein of interest. This process gives raise to much of the protein diversity in humans; therefore, it is not […]

A specific region of the brain, the intra-parietal sulcus (IPS) has reliably been shown, through studies using a variety of methodologies (brain injury, developmental abnormality and neuro-imaging studies), to be a crucial substrate for mathematical competence (Brannon, 2006; Bugden, Price, McLean, & Ansari, 2012; Dehaene, 2004; Dehaene, Piazza, Pinel, & Cohen, 2003; Holloway & Ansari, […]

Reusable plastic crates (RPC’s) are being adopted by the food industry due to the perceived benefits of reduced waste (i.e. paper board), economics and sustainability. However, by reusing crates there is a possibility of distributing contamination from one user to the next if the RPC’s are not sanitized after leaving retailer. Evidence collected over the […]

In order to improve the sustainability of salmonid aquaculture, it is now essential to reduce dietary levels of fish meal by replacement with alternative and terrestrial plant products, and particularly digestible carbohydrates, in the aquafeed formula. However, when fishmeal is substituted at more than 20% by digestible carbohydrates, rainbow trout (Oncorhynchus mykiss), the economically most […]

La présente proposition de recherche porte sur le développement d’un outil de recherche et d’aide à la décision pour la formulation chez le poulet de chair. L’outil de modélisation mathématique permettra de prendre en compte simultanément les mécanismes principaux impliqués dans le métabolisme de P et de Ca et de prédire les relations qui décrivent […]

Deer populations have increased in recent years throughout Europe; deer browsing of plants and tree seedlings is an important contributor to the overall species composition of the forest. Over the last decades, data has been collected in several forests throughout France, measuring deer browsing activities and their effects on the understory diversity, based on fencing […]