Targeting the GAS6/AXL Pathway in Acute Myeloid Leukemia Stem Cells with a Novel Combination Therapy

Blood cancer (leukemia) is common, with ~48,600 and 6,400 new cases expected in the United States and Canada respectively in 2016. The National Cancer Institute (US) calculated an overall 5-year survival rate of 56% for various blood cancers. This is because most current therapies are short-lived; drug resistance and relapse pose significant clinical problems. Life-long […]

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Alkaline treated straw and micro machine technology to improve digestive health and profitability of feedlot cattle

This research will investigate use of calcium oxide treated straw (CaOS) to increase fibre levels in wheat-based feedlot cattle finishing diets. In vitro total gas production will be measured to determine the ideal treatment protocol for creation of CaOS. Further in vitro work will compare fibre digestibility of CaOS to untreated straw, barley silage and […]

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Transitional REM Sleep Brain Connectomes and Seizure Susceptibility

Seizures are rare while dreaming in rapid eye movement (REM) sleep. New research, however, suggests seizures may rebound during unstable REM sleep. This may be due to brain wiring (“connectivity”) since a highly connected brain is more prone to seizures, and connectivity changes from wakefulness to sleep. Brainwave tracings (“EEG”) can generate connectivity maps (“connectomes”) […]

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Optimization of Euglena Fatty Acid Production: an Important Step towards the Commercialization of Euglena Oil

Noblegen Inc. is an advanced bioproducts manufacturer dedicated to developing cost-effective, naturally-derived biomaterials and biochemicals for a wide range of consumer and industry sectors. We employ a unique organism, algae, to continue to do what it does naturally – decontaminate wastewater sustainably and affordably while also generating valuable biomass for use in biomaterials and biochemicals […]

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Minimizing crop stress with micronutrients: Agronomics

When plants are stressed they produce “reactive oxygen species” (ROS). Plants manage ROS with specific enzymes, many of which require micronutrients for activity. In the case of herbicide tolerant crops, the application of herbicide kills weeds in the crop but also stresses the crop for a time. The proposed work will test the hypothesis that […]

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Storytelling Medicine

Fear is considered a natural reaction when a child visits the hospital. Much research has been done to understand what causes it and how to treat it. Current methods to treat child hospital fear works on decreasing anxiety at specific points in the procedure. This project will investigate creating a series of tools and procedures […]

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Formulation and clinical translation of a novel DOX-DelivraTM transdermal treatment for diabetic foot ulcers

This research project aims to develop a novel treatment for diabetic foot ulcers. Individuals with diabetes (3.4 million Canadians) exhibit impaired healing of acute wounds, and 15% (~510,000) are estimated to develop chronic non-healing diabetic foot ulcers (DFUs). DFUs precede 84% of all diabetes related lower leg amputations. Typical DFU treatment is excising devitalised tissue […]

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Acoustic detection of fish presence and depth distribution at the FORCE tidal energy test site in the Bay of Fundy: assessing risk of interaction with tidal turbines

Tidal energy turbines are a new renewable energy technology that will be demonstrated at the FORCE test site in the Bay of Fundy. The potential negative effects of these turbines on fish are of high concern to industry, regulators, fishers, and other stakeholders. This research will use sonars attached to sensor platforms deployed on the […]

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Optimisation de la régie de fertilisation du camerisier

Le camerisier, ou chèvrefeuille comestible (Lonicera caerulea), fait partie des cultures fruitières en émergence au Québec. Toutefois, bien que le camerisier soit cultivé au Québec depuis près d’une décennie, très peu d’information agronomique sur cette culture a été scientifiquement publiée jusqu’à maintenant. Dans l’optique de préciser la régie de la fertilisation pour la camerise, les […]

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