Synthesis of an irreversible inhibitor of Pol?

One aspect of modern drug development involves understanding how enzymes function in terms of the progress of certain diseases in humans. This MITACS project involves the synthesis of small-molecule labels that can bind to a specific enzyme of interest, so as to better understand the mode of action of this enzyme as related to the […]

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Bench – Scale Approach to Understand the Release of Opportunistic Pathogens from Biofilms in Drinking Water Distribution Systems

Legionella pneumophila is an opportunistic pathogen that affects humans that are immunocompromised. It is the most frequently reported drinking water related disease in the United States. In order to investigate its occurrence and release from pipe walls in the drinking water distribution system, a bench – scale method has been designed. Disinfectants (chlorine) and corrosion […]

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Investigating the robustness of gut microbial functions across primates

It remains unclear which factors drives variation in the gut microbiome across humans. Past work has taken an evolutionary perspective and compared the gut microbiome of humans on Western diets to wild primates and humans on non-Western diets and identified particular microbes which are at different abundances. However, the focus of these studies has mainly […]

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Effects of changes in mechanical load on cardiac autoregulation in vivo

The heart beats 3-4 billion times in a person’s lifetime, making it the only part of the body that continues to work – without a break – for one’s entire existence! For this to occur, the heart must be highly regulated, so that is continues to function normally. Much of this regulation occurs within the […]

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Recurrence Interval of Large Earthquakes in the Eastern Himalaya

I designed my master project for performing paleo-seismological research in the eastern Bhutan, where no instrumental or historic earthquake is known and where a historic surface rupture along the Himalayan front was recently identified. Based on the ages of the known large historic earthquakes in the eastern Himalaya, the newly identified surface rupture could have […]

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Detection of Fights in Crowd Video

Detection of fights and anomalous behavior of individuals in a crowd is a common problem in computer vision. Some tools that currently exist rely on optical flow of tracked features is a sequence of video frames. These motion algorithms are sensitive to independently moving objects in the frame. What constitutes an “anomaly” is context (eg. […]

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Mechanisms of the relationship between ageing and dementia.

As our population ages, the burden of dementia is growing. Alzheimer’s disease (AD) is the most common cause of dementia; currently we do not have any disease-modifying treatments for AD. There is motivation to better understand the mechanisms of AD development and expression to control the burden of disease. Frailty is related to neuropathological features […]

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Identifying the Knowledge Gap in Sustainable Financing and Investment for Canadian Investors

Sustainable investment is an expending sector of the mainstream financial market, yet there are few studies evaluating the trends, opportunities, impacts and knowledge gaps as they relate to Canadian investors. Understanding the environmental, social, and governance (ESG) issues related to business operations and investment are critical to understanding trends that are driving this shift towards […]

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Predicting the Ambulance Offload Delay Problem Using Decision Tree Analysis

When emergency departments (EDs) are congested and cannot accept incoming ambulance patients immediately, a common action is to let paramedics continue to provide patient care until an ED bed becomes available. This delay in transferring a patient from the ambulance to the ED is referred to as ambulance offload delay (AOD). AOD is a growing […]

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Improved Industrial Sustainability through Residual Redistribution andRecapture of Value from Underutilized Streams

To maximize usage of residuals and underutilized product streams at Port Hawkesbury Paper (PHP), this investigation is conducted with eco-industrial parks in mind, and a goal of increasing industrial sustainability. The streams investigated could act as a supplement to PHP’s current processes or an external feedstock for a collaborative relationship through waste as a form […]

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