Development, implementation and validation of new anti-E6 therapeutics for the treatment of HPV-associated cancer

Human papillomaviruses (HPVs) are responsible for almost all cervical cancers. Current treatment available relies on chemo- or radiation-therapy or surgery. These methods have several side-effects with high morbidity and survival of just ~ 70%. Our lab, therefore, develops a more patient-centered approach based on targeting the viral E6 protein, the main culprit of carcinogenesis in […]

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Mapping, geochemistry and mineralisation of the Laird Lake area, Red Lake, Ontario

Shear zone-hosted, or orogenic, gold deposits are a significant mineral resource in the Superior Province of Canada. This study will investigate the nature and genesis of gold mineralisation in the Red Lake area of the Uchi subprovince. Recent exploration by Bounty Gold Corp. has identified Au mineralisation in the Laird Lake area close to the […]

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Naturally acquired immunity against important bacterial pathogens in Bruce County First Nations communities

The goal of this proposal is to clarify the reasons for an increased burden of serious bacterial infections caused by two common pathogens: Haemophilus influenzae and Streptococcus pneumoniae in Canadian First Nations. Methodology includes comparative analysis of the critical parameters of naturally acquired immunity against these pathogens in adult First Nations individuals living in two […]

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Sustainable production of engineered wood products in Northwestern Ontario: Developing harmonized decision models and standards for local materials

The global demand for engineered wood products (EWP) is increasing and in the last two decades, timber has captured substantial market shares from the mineral-based solid construction materials, particularly in the construction of residential and non-residential buildings. Although, the production of glue laminated timber (Glulam) and cross laminated timber (CLT) engineered wood products has been […]

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Recovery of fish populations from environmental nanosilver release

Nanosilver is an antimicrobial agent found in thousands of commercial products, frequently released into waterways as a result of their use in clothing and washing machines, as well as many other products with potential for environmental release. Though regulations on environmental release exist for elemental silver, no regulations exist for nanosilver release into the environment. […]

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Real-time fault diagnosis and prediction in structures under earthquake excitation

A large number of civil engineering structures in North America have long survived their expected service life. As they continue to age, there is a significant demand to minimize damage under severe environmental impacts such as earthquake. The main objective of this project is to develop and validate vibration-based monitoring and control strategies using modern […]

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