The impact of climate change on individual and compound extreme events across Eastern Canada – Application to Intensity-Duration-Frequency curves in Labrador City – Year two

The possible failure of surface water management systems is one of the main concerns in the design, construction and management of critical infrastructures such as dams, nuclear facilities and mining activities, especially in northern latitudes. Extreme rainfall and sudden snowmelt events exert major controls on surface runoff and flooding events in cold regions such as […]

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High heat flux microprocessor cooling using binary fluid mixtures

As the heat fluxes produced by modern high-performance microprocessors continue to rise, so too must the effectiveness of the removal of these fluxes. Accordingly, a large amount of research has focused on developing techniques to enhance cooling in computer systems. A novel method of doing so involves replacing the single-phase liquid or two phase-liquid vapor […]

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High heat flux microprocessor cooling using binary fluid mixtures – Year two

As the heat fluxes produced by modern high-performance microprocessors continue to rise, so too must the effectiveness of the removal of these fluxes. Accordingly, a large amount of research has focused on developing techniques to enhance cooling in computer systems. A novel method of doing so involves replacing the single-phase liquid or two phase-liquid vapor […]

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Development of a Cell-Based Signaling Assay to Measure the Potency of a Therapeutic Antibody

Cytokines are proteins that can modulate cellular activity by binding to membrane-bound receptors or soluble receptors. When a cytokine binds to a soluble receptor, it follows the trans-signaling pathway. This signaling pathway induces unique effects on cellular activity which can drive disease progression. This proposal describes the development of a cell-based assay that can be […]

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Rapid evolution of threespine stickleback

I will examine the limits of evolution by investigating morphological and genetic variation of threespine stickleback populations in real time, under the supervision of Dr. Eric Palkovacs at the University of California, Santa Cruz. According to evolutionary theory, organisms experience selective pressures, which can result in adaptation and evolution. Since strong selection events are frequently […]

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Immunomodulatory fusion proteins to treat solid malignancies.

Immunotherapies are transforming conventional cancer treatments with significant improvement of patient survival rates. FDA-approved immunotherapies (immune checkpoint inhibitors, ICIs) have shown remarkable success in the treatment of hematologic malignancies but very low response rate in patients with solid tumors. Therefore, there is an urgent need for novel therapies against solid malignancies. Cura Therapeutics is developing […]

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Burkina Faso Data Use Partnership (DUP) Data Rationalization

The Burkina Faso Data User Partnership is a two-year project with the Ministry of Health (MoH) of Burkina Faso. The aim of the project is to improve the supply of and demand for health data for decision-making at all levels of the healthcare system. A preliminary evaluation, which sought to understand how decisions are being […]

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Developing cultural practices to produce dry beans in Quebec

It is critical for farmers to have the information necessary so that they can make decisions on the best practices to undertake when growing a new crop. Pulse production is growing in demand and is an established market in Canada. In addition, plant based protein products are growing in popularity. We are working on developing […]

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Genome-wide overexpression library in Giardia spp. for drug target discovery

Giardiasis is a foodborne and waterborne disease that affects people worldwide, and it causes enteric diseases with outbreaks of diarrhea in adults and children. There are a few drugs available for treating Giardia spp. infections and they are associated with low efficacy, adverse effects, and drug resistance is spreading. Hence, there is an urgent need […]

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Modélisation mathématique pour l’étude de la motilité cellulaire

La motilité cellulaire joue un rôle central dans un grand nombre de processus physiologiques : la réponse immunitaire, le développement neuronal, le développement des cancers… pour ne citer qu’eux. Comprendre les mécanismes à l’origine des migrations cellulaires, ainsi que les réactions d’interaction est donc crucial. Il est établi que certaines protéines y jouent un rôle […]

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