Aptamer-facilitated Virus Shielding (Apta?ViSh) Technology and Aptamer-facilitated AntivirusShielding (Apta-AntiviSh) Technology to extend the in vivo action of oncolytic viruses. Year One

This project aims to develop an aptamer?based technology to enhance the in?vivo survival of oncolytic viruses and thus the efficiency of virotherapy. Oncolytic viruses (OVs) can selectively replicate in tumor cells, leading to lysis of the tumor. OVs are particularly effective against metastatic cancers, which are especially difficult to treat conventionally. However, OVs can be […]

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Terahertz high-harmonic generation in graphene-metamaterial

Engineering graphene-based devices with exceptional nonlinear optical properties in the terahertz (THz) region play a crucial role in the advancement of THz technologies. We investigate how a metamaterial system consisting of a plasmonic structure enhances THz light-graphene interaction, thus leading to a higher nonlinearity in graphene. A variety of the plasmonic structures will be used […]

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Professional Sport Club Value: Competition Time

Four leagues, the NFL, NHL, NBA and MLB, dominate professional sport in North America. One of the disparities between all four leagues is the number of regular season games played, or for the purpose of this study competition time. There are also large differences between league revenues and thus the study will examine if there […]

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Rigidity of Pham-Brieskorn Threefolds

Algebraic geometry is generally concerned with understanding the properties of geometric objects defined by polynomial equations. These geometric objects, called “varieties”, are points, curves, surfaces and higher dimensional objects. To each variety there is an associated abstract object called a “commutative ring”. It is interesting to try to determine whether a variety contains a certain […]

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Ultrafast Laser Interaction for Chemical and Topological Functionalization of Metallic

This project is to understand the chemical modifications induced by laser irradiation leading to the formation of periodic nanostructures on the surface of metals. Such a study is very significant since it will allow to tune metallic surface properties to control for instance wettability, i.e. whether surfaces are hydrophillic (attract water) or hydrophobic (repel water). […]

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Development of mixed wettability surface for high yield solar desalination

This project focuses on developing a mixed wettability surface to improve the freshwater yield of a solar thermal desalination system. The solar desalination system that will be used for this project is the solar still system. The objective is to find the optimized ratio of high wettability to low wettability area on a polymeric surface […]

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Joint Research Program in Atmospheric Chemistry

The objective of this international collaboration between P.M. Mayer and J. Giorgi at the University of Ottawa and Maxi Burgos Paci at the Universidad Nacional de Córdoba is to understand the fate of reactive organic carbon in the atmosphere. Reactive Organic Carbon (ROC) includes a wide diversity of chemicals that react with atmospheric gases, free […]

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Effects of host plant quality on the transcriptional signatures of flight in migratory butterflies

Migratory insects surpass migratory terrestrial vertebrates in biomass and play essential roles in global ecosystems and agroecosystems serving as pollinators, biological control, or food and nutrient sources. They can also have detrimental effects as vectors of plant and animal diseases or as ecological pests. It is therefore essential for food, ecological, and human security to […]

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Novel Inhibitors of Tissue Transglutaminase

Tissue transglutaminase (TG2) is a protein that is able to mediate the cross-linking of other proteins. The unregulated activity of TG2 is implicated in fibrosis, celiac disease as well as cancer cell survival. Blocking this activity has been shown to decrease tumour size and growth in mice. We have previously designed small molecules that are […]

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Optimal Transport in Quantum Dynamics and Chemistry

In the last 30 years, the theory of optimal transportation has emerged as a fertile field of inquiry, and a diverse tool for exploring applications within and beyond mathematics, in such diverse fields as economics, meteorology, geometry and engineering. More recently, it has empowers today’s machine learning research and become one of the most emerging […]

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Reinforcement-GAN for Network Intrusion Detection

Network intrusion detection systems play a crucial role in computer networks defense. However, most of the existing solutions do not take into account the time-evolving component of the attacks. Attackers are constantly changing the intrusion methods which becomes a serious threat and requires the development of adaptive methods that can cope with these modifications. Moreover, […]

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