Composites cimentaires avec inclusion d’asclépiade

Le retrait est un phénomène de contraction volumétrique des matériaux cimentaires lors de leur prise et durcissement. Il est dû à l’évaporation de l’eau du béton. Ce phénomène n’est pas sans impact sur la fonctionnalité et la durabilité des ouvrages. Car il se caractérise le plus souvent par des fissures qui nuisent aux aspects esthétiques […]

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Developing balanced, wellness, cannabis-based natural products through extraction or cold press

The research will help the partner organization expand their in-house capacity for new product development and commercialization. Focused on wellness and sustainability, the partner aims to leverage green technologies to develop their patient-preferred variety of cannabis, which is current available as dried flower, as a cannabis oil. The partner also seeks to address the underutilization […]

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Construction of an extended cardiac activation map to the torso volume

Cardiac arrhythmia represent a major health issue in Canada, as well as in Europe, as they may lead to sudden death. Accurate means of detection need patients to undergo invasive and perilous exploration, because understanding of electrocardiograms is currently limited. To improve non-invasive detection, it is in particular interesting to understand the physical and mathematical […]

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The Microglia and NLRP3 Inflammasome as a Potential Area of Interest in Understanding the Mechanism of Cerebiome

Chronic stress increases the risk of developing neurodegenerative diseases like Alzheimer’s. Specifically, chronic stress can cause increased microglial activation, leading to the release of pro-inflammatory cytokines through the NLRP3 inflammasome pathway. Pro-inflammatory cytokines play a role in the development and progression of certain brain diseases. Cerebiome has been associated with a reduction of pro-inflammatory cytokines. […]

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Microhémorhéologie

Le sang appartient à une famille des suspensions particulièrement complexe : il s’agit d’une suspension dense de globule rouges très déformables et interagissant entre eux, ils peuvent par exemple s’agréger. Bien qu’étudié depuis les années 70 par les physiologistes, les mécanismes de ses écoulements complexes ne sont toujours pas bien compris. Le but de ce […]

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Uncovering the role of ketogenesis in SGLT2 inhibitor-mediated fatty liver disease

Fatty liver disease, the most common complication of type 2 diabetes (T2D), affects 1 in 5 Canadians. If not managed or treated, a proportion of patients with fatty liver disease may develop the irreversible phases of liver failure, and hepatocellular carcinoma. A new class of drugs, SGLT2 inhibitors (SGLT2i), has been approved by Health Canada […]

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Peptide-based material for heart muscle repair

With over 17 million deaths per year, heart diseases remain the top cause of mortality worldwide. Surgeries such as bypass restore blood supply and save lives. However, after a heart attack the capacity of the heart to pump blood is reduced. In Canada, over 2 million people aged 20+ live with heart disease, costing the […]

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Developing an integrated hydrogen bio-methanation process to enhance and upgrade biogas production in an anaerobic digestion process

The increased energy prices and effects of climate change are severely impacting the day-to-day lives of Canadians. Moreover, essential sectors such as agriculture release substantial amounts of greenhouse gases, adding to climate change challenges. Hence, investing in local and sustainable energy sources is more critical now than ever to reduce these burdens. Therefore, biogas generation […]

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Assessing scientific rigour and 3Rs implementation in Canadian research: Investigating animal use protocols and stakeholder perspectives

Millions of animals are used in research each year. This practice is justified by the expectation that the benefits of such research will be significant, outweighing the harms imposed on animals during experiments. Indeed, animal research has led to countless improvements in human health and quality of life. However, there is growing concern that current […]

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Manitoba Mathematics Action Research Project

Recently PLS has signed a contract with the Ministry of Education in Manitoba. The province has been experiencing declining math scores across the province in both international tests such as PISA and in their provincial standardized tests. Manitoba is deeply committed to improving students mathematical achievement and as a result has hired PLS to develop […]

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Development of Spatial Normalization Methods for Ventilation-Perfusion Scintigraphic Images

Ventilation-perfusion (V/Q) scintigraphy has a major role to play in the diagnosis of pulmonary embolism (PE). V/Q scintigraphy rather helps infer the presence of PE based on compromised perfusion of the occluded segmental and sub-segmental pulmonary arteries. Therefore, expert knowledge of the bronchopulmonary segmental anatomy on the various 2D planar projections of the lung and […]

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Development of field-ready AI model for estimation of compressive strength of concrete using non-destructive testing methods

The proposed project aims to apply artificial intelligence methods to augment in-place non-destructive testing technologies in order to reduce or eliminate the need for intrusive methods (i.e. concrete core extraction) for concrete strength estimation. The proposed approach is based on the SonReb method, which combines two non-destructive testing technologies, namely ultrasonic pulse velocity and rebound […]

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