Development of Fungal-selective Yck2 Inhibitors to Combat Drug-resistant Invasive Fungal Diseases

Invasive fungal infections represent a major threat to human health that is exacerbated by the widespread emergence of antifungal drug resistance. Existing therapies are already limited in number, largely due to the similarity between fungal and human cells. As such, new antifungal approaches are urgently needed to combat drug-resistant fungal pathogens. We have previously implicated […]

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Exploring the Experiences of Canadian Black Planning Professionals

This project will document the experiences of Black planning professionals and promote discussions to explore and address anti-Black and systemic racism within the field of planning, a field tasked with building cities in the public interest. It aims to create inclusion and support in the field of urban and regional planning by amplifying the voices […]

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Investing in Recovery: Strengthening Employer and Policy Roles in Labour Market Integration of Canada’s Immigrant Women in STEM

The goal of our project titled Investing in Recovery: Strengthening Employer and Policy Roles in Labour Market Integration of Canada’s Immigrant Women in STEM will be to produce new research rooted in a power analysis around the specific challenges that Canada’s immigrant women in STEM face, including the perspective of STEM employers on the opportunity […]

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The effect of privacy upon online health disclosure

How much medical knowledge is stored in each of our own family trees? When family members share health information with one another, does this lead to higher rates of genetic health screening and better health outcomes? Do perceptions about the privacy of health information affect the rate at which we share this information? This work […]

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Investigating WD repeat protein function in the nucleolar biology and cancer

Ribosome biosynthesis is one of the most multifaceted and energy-demanding processes in biology. It involves over 250 factors that transiently associate with the nascent pre-ribosome in a well-orchestrated manner. Importantly, increased ribosome biogenesis has a critical role in cancer initiation and progression. Owing to the advances in cryo-electron microscopy, this pathway’s detailed mechanism started to […]

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Investigating WD repeat protein function in the nucleolar biology and cancer – Year two

Ribosome biosynthesis is one of the most multifaceted and energy-demanding processes in biology. It involves over 250 factors that transiently associate with the nascent pre-ribosome in a well-orchestrated manner. Importantly, increased ribosome biogenesis has a critical role in cancer initiation and progression. Owing to the advances in cryo-electron microscopy, this pathway’s detailed mechanism started to […]

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Software and Algorithms for Quantum Computational Chemistry

This project is focused on improving the theory, software and scope of applications of quantum computational chemistry. The intern will work with the company research team to further develop new theoretical methods which are under development, implement them into code as part of the existing open-source PennyLane package, and run tests for modelling the vibrational […]

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Generating Contextually Appropriate Followup Questions

The goal of this internship is to design and build a model which can generate contextually appropriate questions during a market research survey. This project will build on existing work, and will extend it by incorporating commonsense reasoning, long-range memory, and possibly other features The model will be tested with real humans using an online […]

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Coping With Pandemic Through Software Development Support

The onset of COVID-19 pandemic has posed major challenges in Geomechanica, a small organization that develops a state-of-the-art simulation tool (Irazu) for the civil, mining, and petroleum engineering industries their business. The company is seeing budget cuts in client base and global economic slowdown to inefficiencies caused by remote work setups of their employees. As […]

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CFD Analysis of the Microsys Cold Gas InflationSystem

Microsys is a Mississauga company that designs and sells specialized test equipment to airbag manufacturers worldwide. The Cold Gas Inflation System (CGS) allows these manufacturers to test the inflation characteristics of airbag systems in a simple, safe, and inexpensive manner. The CGS involves the rapid discharge of a compressed gas, which the company would like […]

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Accelerating Cycling Uptake Through Community based Social Marketing

Through the use of a community-based social marketing strategy that focuses on perceived benefits and barriers to urban cycling for transportation, the research project will serve to expand the services and usage of BikeChain: the University of Toronto’s not for profit bicycle repair shop. The work will increase the reach of BikeChain’s services within the […]

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