Single domain antibodies (sdAbs) represent a versatile class of heavy chain antibodies lacking a paired light chain and encoded by VHH germline genes typically expressed in camelids. KisoJi Biotech has developed a transgenic mouse line in which each mouse expresses multiple camelid VHH genes capable of specifically binding any antigen of interest. The small molecular […]

Single domain antibodies (sdAbs) represent a versatile class of heavy chain antibodies lacking a paired light chain and encoded by VHH germline genes typically expressed in camelids. KisoJi Biotech has developed a transgenic mouse line in which each mouse expresses multiple camelid VHH genes capable of specifically binding any antigen of interest. The small molecular […]

Sudden Unexpected Death in Epilepsy (SUDEP), the commonest cause of death in epilepsy, is the most feared complication. SUDEP usually occurs following a seizure, most often in patients who are non-responsive to antiepileptic drugs. These patients are typically found dead in bed following respiratory apnea and cardiac arrest. Our group has shown that seizures in […]

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseases such as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer […]

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseases such as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer […]

The workflow of pathologists will soon be revolutionized with the introduction of digital pathology allowing pathologists to view tissue samples as a digital image on a computer workstation. Such a conversion from traditional microscopy will bring many benefits to the pathologist’s workflow aiming to boost significant efficiency as well as ergonomic benefits. However, much work […]

Invasive fungal infections represent a major threat to human health that is exacerbated by the widespread emergence of antifungal drug resistance. Existing therapies are already limited in number, largely due to the similarity between fungal and human cells. As such, new antifungal approaches are urgently needed to combat drug-resistant fungal pathogens. We have previously implicated […]

This project will document the experiences of Black planning professionals and promote discussions to explore and address anti-Black and systemic racism within the field of planning, a field tasked with building cities in the public interest. It aims to create inclusion and support in the field of urban and regional planning by amplifying the voices […]

The goal of our project titled Investing in Recovery: Strengthening Employer and Policy Roles in Labour Market Integration of Canada’s Immigrant Women in STEM will be to produce new research rooted in a power analysis around the specific challenges that Canada’s immigrant women in STEM face, including the perspective of STEM employers on the opportunity […]

How much medical knowledge is stored in each of our own family trees? When family members share health information with one another, does this lead to higher rates of genetic health screening and better health outcomes? Do perceptions about the privacy of health information affect the rate at which we share this information? This work […]

Ribosome biosynthesis is one of the most multifaceted and energy-demanding processes in biology. It involves over 250 factors that transiently associate with the nascent pre-ribosome in a well-orchestrated manner. Importantly, increased ribosome biogenesis has a critical role in cancer initiation and progression. Owing to the advances in cryo-electron microscopy, this pathway’s detailed mechanism started to […]

Ribosome biosynthesis is one of the most multifaceted and energy-demanding processes in biology. It involves over 250 factors that transiently associate with the nascent pre-ribosome in a well-orchestrated manner. Importantly, increased ribosome biogenesis has a critical role in cancer initiation and progression. Owing to the advances in cryo-electron microscopy, this pathway’s detailed mechanism started to […]