Discovery of Novel E3 Ligands for PROTAC Development

Protein degradation induced by PROTACs (PROteolysis TArgeting Chimeras) constitutes a novel modality of drug discovery, with advantages over the traditional approach. This approach is still at infancy and there is a lot to learn in this field. The trainees will work under academic supervisors at University of Toronto, who are experts in chemical tool development […]

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A Dexterous Needlescopic Instrument using Soft Robotics for Minimally Invasive Surgery

Robotic-assisted surgical systems have enabled minimally invasive procedures to reduce recovery time and traumas compared to conventional open surgery. Even though there exist some examples of systems capable of accessing remote places within the body, e.g., the current commercial systems are limited by their large size, high cost, and inability to navigate in tortuous paths. […]

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Designing and Developing Interaction techniques for webspaces in AR/VR

The objective of this project is to design and develop interaction techniques for Webspaces in Virtual/Augmented Reality. We will study and understand current techniques to interact with the websites via screens, how users access the information and media presented on the websites and the ways in which this presentation of information can be improved to […]

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Advanced machine learning techniques for ore body modelling

Geostatistical techniques offer a means of mathematically approximating the spatial patterns of geological parameters. The geostatistical interpolation and simulation methods are commonly used for modeling ore bodies. The accuracy of these models has significant impacts on the reliability of mine planning and design. The proposed research project aims to apply advanced machine learning methods, geared […]

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Design of a Multi-modal Electronic Stethoscope for the Digital Acquisition and Automatic Diagnosis of Auscultation Signals

The proposed research project aims to develop a multi-modal stethoscope, containing superior digitized heart and lung sounds, telemedicine capabilities and assistive diagnostics. This is achieved by leveraging new advancements in piezo, microphone, wireless and machine learning technologies. The project will investigate these technologies and integrate them into custom made electronics and mechanical designs to achieve […]

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Bridging immunology and within-host ecology in malaria infection

Linking proximate mechanisms of immune responses to host health and parasite burden is key to predicting individual infection outcome. However, existing mathematical models fall short as they leave out mechanistic details of host responses. My work bridges the gap between mechanistic immunology and infection ecology by incorporating a process-based description of host responses into a […]

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An evaluation of the impact of the Fearless Physical Activity Program and the Canadian Congenital Heart Alliance’s online resources using the RE-AIM framework

This study aims to evaluate the instructor manuals of the Canadian Congenital Heart Alliance’s Fearless Physical Activity event. The hosts are provided with these manuals prior to each event session. These instructors will be provided with an evaluation checklist, and will be interviewed, post-event, to assess the instructor resources. The objective is to determine whether […]

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Exploring medical potential of cannabinoids

Evaluating the medicinal use of cannabinoids represents an area of massive untapped potential, especially considering its upcoming legalization in Canada. Currently, a significant proportion of medical cannabis research is based on self-reported use and outcomes, rather than carefully-designed research studies. Here, we aim to better understand the impact of cannabis administration in adults with obesity […]

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Sputtered Silver-Dielectric Structures for Memristor Devices

Memristor, as the name suggests is a contraction of “memory resistor”, a novel device that was proposed almost fifty years but only realized recently for the first time. Memristor, the missing link in the manifold of circuit elements, is expected to usher a wave of innovative integrations in electronics and yield novel functionalities. Memristors would […]

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