Investigating Parkin Oxidation and its Impact on Parkinson’s Neurodegeneration

Parkinson’s disease (PD), a devastating neurodegenerative condition, is becoming increasingly prevalent in our aging population, yet the events leading to neuron death remain unclear. Current treatments aim to alleviate symptoms, but none address the cause of neurodegeneration, leaving a cure for PD elusive. Disease progression is marked by significant neuron loss in the brain region […]

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Oxidative stress-induced Nrf2 misfolding in Parkinson’s disease

Oxidative stress and aging are the primary risk factors for Parkinson’s disease (PD). The protein Nrf2 is particularly important in fighting oxidation and the associated damage in the brain as it activates antioxidant enzymes. Nrf2 is regulated by another protein called Keap1. These two proteins can get damaged under excessive oxidative stress conditions and thus […]

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The Connected Workplace: Private Industry

This project will focus on the use of wireless technologies in the Canadian private sector work environment. Wireless is the fastest growing area of Canadian communications. Despite enormous growth for personal use, recent market data demonstrates the workplace remains a largely underdeveloped market for wireless service providers. The overall purpose of this project is to […]

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BRIGHTLANE: Creating a Home for a Community of Entrepreneurs

BRIGHTLANE: Launching an Incubator” is a research project that will explore and evaluate different traditional approaches to creating supportive environments for startup business. Co-working spaces have seen enormous growth in recent years and people seek the support and savings associated with a shared workspace. This project will provide foundational research to facilitate the launch of […]

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Mitacs Accelerate Fellowship

The proposed research project focuses on understanding how to better prevent and respond to cholera outbreaks, particularly in impoverished areas lacking clean water and proper sanitation. Despite having the tools to prevent cholera, most efforts are reactive rather than proactive, meaning resources are often mobilized only after an outbreak occurs. The study will analyze the […]

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A 3D-Printed Smart Insole for Plantar Pressure and Foot Orientation Monitoring

Imagine shoes with built-in sensors that can track how your feet move! This internship project is about developing insoles with special air pockets that sense pressure. These insoles would be 3D-printed for a perfect fit and could be worn during regular human movement. By comparing this data with existing methods like pressure plates, we’ll see […]

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Additive Manufacturing for Prototype Development in Prosthetic Treatment Delivery

Beacon Ortho hopes to identify and deliver additively manufactured devices to improve the patient experience, improved fit and comfort, and to reduce the extremely high amount of input waste in fabrication of prosthetic devices. This project aims to test additively manufactured trial devices against moulded thermoplastic trial devices, and composite definitive devices. Using ISO 10328 […]

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Numerical Simulations for Plowing Soil Process

The industrial drainage plow is a mechanized tool used for the installation of agricultural drainage and land reclamation. This research aims to optimize the plow’s shape for various soil conditions to increase the tile installation speed and the service life, and to reduce the drag force, which will reduce the fuel consumption. Numerical methods will […]

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Cryptocurrency Adoption in Canada

This research project aims to help the Bank of Canada understand how people in Canada are using cryptocurrencies like Bitcoin. Cryptocurrencies are becoming more popular, but their prices often have large fluctuations, which can make them risky to use. By studying survey data, the project will explore how Canadians include cryptocurrencies in their investments and […]

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The Connected Workplace: Public Sector

The workplace remains a largely underdeveloped market for wireless service providers. This project will focus on the use of wireless technologies in the Canadian Public Sector workplace. The overall purpose is to better understand the obstacles to technology adoption in the workplace, and offer actionable recommendations on how to mitigate them. The work will be […]

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Role of Anterior Cingulate Cortex in Physician and Emotional Symptoms of Opioid Withdrawal

With the number of opioid-related deaths continuing to rise, the demand for an effective treatment for opioid use disorder (OUD) is growing. While opioid antagonists are effective, compliance is an issue since they induce withdrawal. The botanical compound, TGIR-C is a promising non-opioid alternative that treats detoxification without inducing withdrawal. Further research on its neural […]

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