Identifying Tissue Protective Probiotics and Their Immunomodulatory Properties

The gut microbiota, a complex community of microorganisms residing within the digestive tract, plays a significant role in modulating host immune responses. This project aims to identify specific gut microbial species that influence the immune response and elucidate the underlying molecular mechanisms involved. To study these microbe-host interactions, mice cells will be exposed to different microorganisms, subsequently quantifying their release of signaling molecules, i.e. cytokines. A particular focus will be placed on the cytokine interferon-gamma because it has recently been discovered that this signaling molecule is involved in an additional mechanism to protect the host by improving disease tolerance.
In cooperation with Lallemand Health Solutions, a company specializing in probiotic development, this research will contribute to the refinement of existing probiotic formulations and the development of novel probiotic products. These advancements are expected to enhance Lallemand’s product portfolio and potentially contribute to improved human health.

Faculty Supervisor:

Irah King

Student:

Partner:

Lallemand Health Solutions Inc (Montreal, QC)

Discipline:

Life Sciences

Sector:

Agriculture; Manufacturing; Professional, scientific and technical services

University:

Research Institute of the McGill University Health Centre

Program: