Development of Pharmacological Probes for Road-Mapping WD40 Domain Proteins

Since the dawn of the human genome sequencing in 2003, great hopes have been put into the development of new therapeutics and personalized medicine tailored on individual DNA profiles. Nonetheless, progress in these fields has been slow, mainly due to the focus of the research community on only a small number of genes and proteins […]

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The application and validation of predictive models to establish indices of protein quality in companion animal feed ingredients

This project will result in the generation of mathematical models that will predict the quality and sustainability of protein-based ingredients that are commonly used in dog diets. With the projected growth of human and pet populations, and increases in food production necessary to meet growing demands, providing Canadian pet food companies (such as our industry […]

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En Route to Discovery of Potential ‘Green’ Refrigerants

Refrigerants have a wide range of applications in Canada, from their support for the food industry (storage and transport) to their key role in recreational sports like hockey, curling and ice-skating. Although current hydrofluorocarbon refrigerants have solved previous problems associated with depletion of the earth’s ozone layer, they still suffer from high global warming potentials. […]

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En Route to Discovery of Potential ‘Green’ Refrigerants – Year two

Refrigerants have a wide range of applications in Canada, from their support for the food industry (storage and transport) to their key role in recreational sports like hockey, curling and ice-skating. Although current hydrofluorocarbon refrigerants have solved previous problems associated with depletion of the earth’s ozone layer, they still suffer from high global warming potentials. […]

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Safety and effectiveness of Mifegymiso® offered through different service delivery points: a national prospective cohort study

Medication abortion with mifepristone and misoprostol has the potential to advance women’s access to safe and geographically accessible abortion care. Improved access to medication abortion protects women’s right to health and supports women’s autonomy and agency. However, the over-regulation of mifepristone in much of the Global North has muted the promise of this pill-based regimen […]

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Safety and effectiveness of Mifegymiso® offered through different service delivery points: a national prospective cohort study – Year two

Medication abortion with mifepristone and misoprostol has the potential to advance women’s access to safe and geographically accessible abortion care. Improved access to medication abortion protects women’s right to health and supports women’s autonomy and agency. However, the over-regulation of mifepristone in much of the Global North has muted the promise of this pill-based regimen […]

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Validation of the Babbly language development app

This study will validate the accuracy of a new artificial intelligence (AI) powered application, which has been developed to track communication and cognition during the babbling stages of development in the first year of life. Once validated, this app will be an asset to both parents and clinicians. It will be used by parents and […]

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Validation of the Babbly language development app – Year two

This study will validate the accuracy of a new artificial intelligence (AI) powered application, which has been developed to track communication and cognition during the babbling stages of development in the first year of life. Once validated, this app will be an asset to both parents and clinicians. It will be used by parents and […]

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Understanding the gaps in the adoption of animal care practices in Canada – Year two

Welfare issues such as lameness and body injuries (LBI) negatively impact health, productivity, and longevity of dairy cows. Despite research, regulatory and outreach efforts, the current prevalence of LBI is high in Canada and shows little evidence of improvement. The proposed study will use an integrated, structured approach to identify gaps influencing the adoption of […]

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Impact of microparticles in cancer progression

Blood platelets are the principal source of cells known to shed small extracellular vesicles which package biologically active molecules. We have recently identified a new type of these vesicles (called microparticles/MPs) that contain mitochondria, which represent the energy producing motors for living cells. We have also discovered that MPs preferentially bind and internalize into leukemia […]

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Impact of microparticles in cancer progression – Year two

Blood platelets are the principal source of cells known to shed small extracellular vesicles which package biologically active molecules. We have recently identified a new type of these vesicles (called microparticles/MPs) that contain mitochondria, which represent the energy producing motors for living cells. We have also discovered that MPs preferentially bind and internalize into leukemia […]

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Epigenetic Regulators of Anticancer Drug Response

The effectiveness of cancer drugs depends on several factors which are governed by the genetic and ‘epigenetic’ code of cancer cells. The epigenetic code comprises those heritable modifications that bookmark DNA and DNA-associated proteins to guide the expression of genetic attributes without changing the DNA sequence. This epigenetic code is written, read, and erased by […]

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